Gαs Protein Expression Is an Independent Predictor of Recurrence in Prostate Cancer

Table 5

Univariate and Multivariate analysis of clinical factors in relation to overall survival.

	Univariate; HR (95% CI)	𝑃	Multivariate; HR (95% CI)	𝑃
Negative Gαs	5.832 (3.232–10.763)	<0.001*	3.904 (1.278–5.873)	<0.001*
Age at diagnosis	1.098 (0.921–1.284)	0.495	1.328 (0.493–4.187)	0.276
Clinical stage at diagnosis	2.287 (1.639–3.121)	<0.001*	0.723 (0.298–1.114)	0.294
Gleason score at diagnosis	3.809 (2.778–5.132)	<0.001*	2.153 (1.471–9.357)	0.004*
Preoperative PSA	2.673 (2.007–3.297)	<0.001*	2.158 (0.622–3.192)	0.429
Angiolymphatic invasion	1.224 (1.098–1.989)	0.004*	1.472 (0.897–1.677)	0.172
Extraprostatic extension	1.327 (1.211–2.019)	0.031*	0.819 (0.531–1.396)	0.491
Positive margin	2.127 (1.271–4.918)	0.009*	1.211 (0.682–2.198)	0.514
Seminal vesicle invasion	1.778 (1.281–3.711)	0.046*	1.397 (0.723–2.187)	0.283
Positive lymph node	1.698 (0.831–3.781)	0.064	0.931 (0.871–2.011)	0.592

CI: confidence interval; HR: hazard ratio; rec: recurrence.
*Significant relationships of clinical factors with overall survival.