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Journal of Immunology Research
Volume 2014, Article ID 308732, 6 pages
Research Article

Fusion-Expressed CTB Improves Both Systemic and Mucosal T-Cell Responses Elicited by an Intranasal DNA Priming/Intramuscular Recombinant Vaccinia Boosting Regimen

1Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China
2Institute of Biomedical Science, Fudan University, Shanghai 200032, China

Received 13 November 2013; Accepted 7 March 2014; Published 1 April 2014

Academic Editor: Diane Williamson

Copyright © 2014 Sugan Qiu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The fusion expressed CTB could improve specific T cell responses elicited by TRIVN (Tat, Rev, Integrase, Vif and Nef fusion antigen derived from HIV-1). However, when separating TRIVN and CTB into two DNA vaccines, the genetic adjuvant effect decreased.

  1. Supplementary Material