Research Article

Human Adipose Tissue Macrophages Are Enhanced but Changed to an Anti-Inflammatory Profile in Obesity

Figure 2

Polarization of anti- and proinflammatory macrophage markers in lean and obese subjects. Difference in phenotype of macrophage markers is expressed in subcutaneous abdominal adipose tissue samples from lean ( ) and obese ( ) subjects. Gene-expression levels of macrophage markers are presented relative to CD14, measured by RT-PCR. Lean versus obese analyzed by a Wilcoxon Mann-Whitney rank sum test. The ratio between the anti-inflammatory markers CD163, CD206, and IL-10 ((a)–(c)). The ratio between the proinflammatory markers IL-6, MCP-1, and TNF-α ((d)–(f)). * . Graph showing each outliner and mean value with a solid line.
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