Human Adipose Tissue Macrophages Are Enhanced but Changed to an Anti-Inflammatory Profile in Obesity
Figure 2
Polarization of anti- and proinflammatory macrophage markers in lean and obese subjects. Difference in phenotype of macrophage markers is expressed in subcutaneous abdominal adipose tissue samples from lean () and obese () subjects. Gene-expression levels of macrophage markers are presented relative to CD14, measured by RT-PCR. Lean versus obese analyzed by a Wilcoxon Mann-Whitney rank sum test. The ratio between the anti-inflammatory markers CD163, CD206, and IL-10 ((a)–(c)). The ratio between the proinflammatory markers IL-6, MCP-1, and TNF-α ((d)–(f)). *. Graph showing each outliner and mean value with a solid line.