Current Concepts and Future Directions for the Assessment of Autoantibodies to Cellular Antigens Referred to as Anti-Nuclear Antibodies

Table 6

Overview of defined ANA patterns (modified from Wiik et al., 2010 [13]).

Pattern group	Pattern
Nuclear envelope; (membrane)	Smooth nuclear envelope
	Punctate nuclear envelope
Nuclear	Homogeneous pattern
	Large speckled
	Coarse speckled
	Fine speckled
	Fine grainy Scl-70-like
	Pleomorphic speckled (i.e., PCNA)
	Centromere
	Multiple nuclear dots
	Coiled bodies (few nuclear dots)
	Dense fine speckled
	Isolated metaphase chromosomes
Nucleolar	Homogeneous nucleolar
	Clumpy nucleolar
	Punctate nucleolar
Mitotic spindle; apparatus	Centriole (centrosome)
	Spindle pole (NuMa) (MSA-1) (HSeg5)
	Spindle fiber
	Midbody (MSA-2)
	CENP-F (MSA-3)
Cytoplasmic	Diffuse
	Fine speckled
	Mitochondrial
	Discrete dots: GW bodies,; endosomes, lysosomes
	Golgi complex
	Intercellular contact proteins
	Fibers and cytoskeleton
	Rods and rings
Negative