IFN-γ-Secreting-Mesenchymal Stem Cells Exert an Antitumor Effect In Vivo via the TRAIL Pathway
Figure 5
MSCs IFN-γ inhibit tumor mass growth in nude mice. (a) Tumor sizes were dynamically monitored after H460 cells combined with or without MSCs or MSCs IFN-γ were injected into nude mice ( mice/group, three separate experiments). (b) The tumor mass weight and morphology were compared at the end of the incubation period in vivo. The asterisks indicate . (c) Hematoxylin and eosin (H&E) staining of xenograft tumor. Tumor mass containing MSCs IFN-γ showed a serious extent of necrotic area, compared with the other two groups.
