The Robust and Modulated Biomarker Network Elicited by the Plasmodium vivax Infection Is Mainly Mediated by the IL-6/IL-10 Axis and Is Associated with the Parasite Load

Table 1

Study population.

Characteristics	Healthy donors HD	Malaria patients MAL
Gender, male/female	11/26	53/24
Median age, years (range)	27 (19–45)	35 (18–73)
Number of malaria episodes, 𝑛 (%)
1st	—	15 (19.5)
<5	—	35 (45.4)
≥5	—	27 (35.1)
Parasitemia (parasites/mm^3),  𝑛 (%)
Low, ≤500	—	39 (50.6)
High, >500	—	38 (49.4)
Symptoms, 𝑛 (%)
Fever	—	53 (68.8)
Myalgia	—	64 (83.1)
Headache	—	71 (92.2)
Chills	—	58 (75.3)
Sweating	—	42 (54.5)
Weakness	—	67 (87.0)
Hematological records
Hemoglobin levels g/dL, median (range)	13.1 (11.4–16.2)	13.3 (8.4–17.1)
Hematocrit %, median (range)	38.2 (32.1–46.9)	39.2 (24.0–49.9)
Red blood cells ×10^6/mm^3, median (range)	4.1 (3.4–5.7)	4.1 (2.6–5.3)
White blood cells ×10^3/mm^3, median (range)	5.9 (3.6–11.6)	4.4 (1.4–9.0)
Platelets ×10^3/mm^3, median (range)	242.0 (136.0–442.0)	119.0 (20.0–270.0)