TGF-<i>β</i>: An Important Mediator of Allergic Disease and a Molecule with Dual Activity in Cancer Development

<table>The TGF-<i>β</i> canonical signaling pathway. After the ligand binds to T<i>β</i>RII, the TGF-<i>β</i> receptors are dimerized and recruit Smad proteins. The Smad2 and/or Smad3 complex is phosphorylated by T<i>β</i>RI and forms a complex with Smad4. This complex subsequently translocates to the nucleus where it binds to specific transcription factors (TF) and induces the transcription of TGF-<i>β</i> dependent genes.</table>

Journal of Immunology Research

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Figure 2: TGF-<i>β</i>: An Important Mediator of Allergic Disease and a Molecule with Dual Activity in Cancer Development 

Journal of Immunology Research

TGF-β: An Important Mediator of Allergic Disease and a Molecule with Dual Activity in Cancer Development

Figure 2