Table of Contents Author Guidelines Submit a Manuscript
Journal of Immunology Research
Volume 2014, Article ID 325938, 6 pages
http://dx.doi.org/10.1155/2014/325938
Research Article

Antibodies to Lactobacilli and Bifidobacteria in Young Children with Different Propensity to Develop Islet Autoimmunity

1Immunology Group, Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila 19, 50411 Tartu, Estonia
2Department of Pediatrics, University of Oulu, Kajaanintie 50, 90014 Oulu, Finland
3Children’s Hospital, University of Helsinki and Helsinki University Central Hospital, Tukholmankatu 8 A, 00029 Helsinki, Finland
4Department of Pediatrics, Tampere University Hospital, Teiskontie 35, 33521 Tampere, Finland
5Folkhälsan Research Center, Haartmansg 8, 00290 Helsinki, Finland
6Department of Pediatrics, University of Turku, 20014 Turku, Finland
7Immunogenetics Laboratory, University of Turku, 20014 Turku, Finland
8University of Eastern Finland, Yliopistonranta 1, 70211 Kuopio, Finland
9Department of Microbiology, University of Tartu, Ravila 19, 50411 Tartu, Estonia
10Centre for Translational Medicine, University of Tartu, Ravila 19, 50411 Tartu, Estonia

Received 18 November 2013; Revised 16 January 2014; Accepted 20 January 2014; Published 4 March 2014

Academic Editor: Jacek Tabarkiewicz

Copyright © 2014 Ija Talja et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Taplin and J. Barker, “Autoantibodies in type 1 diabetes,” Autoimmunity, vol. 41, no. 1, pp. 11–18, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. K. Vehik, M. J. Haller, C. A. Beam et al., “Islet autoantibody seroconversion in the DPT-1 study: justification for repeat screening throughout childhood,” Diabetes Care, vol. 34, no. 2, pp. 358–362, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Knip, S. Korhonen, P. Kulmala et al., “Prediction of type 1 diabetes in the general population,” Diabetes Care, vol. 33, no. 6, pp. 1206–1212, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. K. Salminen, K. Sadeharju, M. Lönnrot et al., “Enterovirus infections are associated with the induction of β-cell autoimmunity in a prospective birth cohort study,” Journal of Medical Virology, vol. 69, no. 1, pp. 91–98, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Wahlberg, J. Fredriksson, E. Nikolic et al., “Environmental factors related to the induction of beta-cell autoantibodies in 1-yr-old healthy children,” Pediatric Diabetes, vol. 6, no. 4, pp. 199–205, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. A. T. Borchers, R. Uibo, and M. E. Gershwin, “The geoepidemiology of type 1 diabetes,” Autoimmunity Reviews, vol. 9, no. 5, pp. A355–A365, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. E. J. Schiffrin and S. Blum, “Interactions between the micrbiota and the intestinal mucosa,” European Journal of Clinical Nutrition, vol. 56, pp. 560–564, 2002. View at Google Scholar
  8. F. He, A. C. Ouwehand, E. Isolauri, H. Hashimoto, Y. Benno, and S. Salminen, “Comparison of mucosal adhesion and species identification of bifidobacteria isolated from healthy and allergic infants,” FEMS Immunology and Medical Microbiology, vol. 30, no. 1, pp. 43–47, 2001. View at Publisher · View at Google Scholar · View at Scopus
  9. E. Furrie, “Probiotics and allergy,” Proceedings of the Nutrition Society, vol. 64, no. 4, pp. 465–469, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. Y. M. Sjögren, S. Tomicic, A. Lundberg et al., “Influence of early gut microbiota on the maturation of childhood mucosal and systemic immune responses: gut microbiota and immune responses,” Clinical and Experimental Allergy, vol. 39, no. 12, pp. 1842–1851, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. G. Hörmannsperger and D. Haller, “Molecular crosstalk of probiotic bacteria with the intestinal immune system: clinical relevance in the context of inflammatory bowel disease,” International Journal of Medical Microbiology, vol. 300, no. 1, pp. 63–73, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. A. C. Ouwehand, E. Isolauri, F. He, H. Hashimoto, Y. Benno, and S. Salminen, “Differences in Bifidobacterium flora composition in allergic and healthy infants,” Journal of Allergy and Clinical Immunology, vol. 108, no. 1, pp. 144–145, 2001. View at Google Scholar · View at Scopus
  13. J. Štšepetova, E. Sepp, K. Julge, E. Vaughan, M. Mikelsaar, and W. M. De Vos, “Molecularly assessed shifts of Bifidobacterium ssp. and less diverse microbial communities are characteristic of 5-year-old allergic children,” FEMS Immunology and Medical Microbiology, vol. 51, no. 2, pp. 260–269, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. M. Sjögren, M. C. Jenmalm, M. F. Böttcher, B. Björkstén, and E. Sverremark-Ekström, “Altered early infant gut microbiota in children developing allergy up to 5 years of age,” Clinical and Experimental Allergy, vol. 39, no. 4, pp. 518–526, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. N. Takahashi, H. Kitazawa, N. Iwabuchi et al., “Immunostimulatory oligodeoxynucleotide from Bifidobacterium longum suppresses Th2 immune responses in a murine model,” Clinical and Experimental Immunology, vol. 145, no. 1, pp. 130–138, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Medina, E. Izquierdo, S. Ennahar, and Y. Sanz, “Differential immunomodulatory properties of Bifidobacterium logum strains: relevance to probiotic selection and clinical applications,” Clinical and Experimental Immunology, vol. 150, no. 3, pp. 531–538, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. A. L. Hart, K. Lammers, P. Brigidi et al., “Modulation of human dendritic cell phenotype and function by probiotic bacteria,” Gut, vol. 53, no. 11, pp. 1602–1609, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Kalliomäki, S. Salminen, H. Arvilommi, P. Kero, P. Koskinen, and E. Isolauri, “Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial,” Lancet, vol. 357, no. 9262, pp. 1076–1079, 2001. View at Publisher · View at Google Scholar · View at Scopus
  19. F. Yan, H. Cao, T. L. Cover et al., “Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism,” Journal of Clinical Investigation, vol. 121, no. 6, pp. 2242–2253, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. A.-L. Prangli, M. Utt, I. Talja et al., “Antigenic proteins of Lactobacillus acidophilus that are recognised by serum IgG antibodies in children with type 1 diabetes and coeliac disease,” Pediatric Allergy and Immunology, vol. 21, no. 4, pp. e772–e779, 2010. View at Google Scholar · View at Scopus
  21. I. Nilsson, I. Kornilovs'ka, S. Lindgren, Å. Ljungh, and T. Wadström, “Increased prevalence of seropositivity for non-gastric Helicobacter species in patients with autoimmune liver disease,” Journal of Medical Microbiology, vol. 52, no. 11, pp. 949–953, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. A. J. Macpherson, M. B. Geuking, E. Slack, S. Hapfelmeier, and K. D. McCoy, “The habitat, double life, citizenship, and forgetfulness of IgA,” Immunological Reviews, vol. 245, no. 1, pp. 132–146, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Aumeunier, F. Grela, A. Ramadan et al., “Systemic toll-like receptor stimulation suppresses experimental allergic asthma and autoimmune diabetes in NOD mice,” PLoS ONE, vol. 5, no. 7, Article ID e11484, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. P. López, M. Gueimonde, A. Margolles, and A. Suárez, “Distinct Bifidobacterium strains drive different immune responses in vitro,” International Journal of Food Microbiology, vol. 138, no. 1-2, pp. 157–165, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. D. R. Kramer, R. M. Sutherland, S. Bao, and A. J. Husband, “Cytokine mediated effects in mucosal immunity,” Immunology and Cell Biology, vol. 73, no. 5, pp. 389–396, 1995. View at Google Scholar · View at Scopus
  26. F. He, H. Morita, H. Hashimoto et al., “Intestinal Bifidobacterium species induce varying cytokine production,” Journal of Allergy and Clinical Immunology, vol. 109, no. 6, pp. 1035–1036, 2002. View at Publisher · View at Google Scholar · View at Scopus
  27. A. Giongo, K. A. Gano, D. B. Crabb et al., “Toward defining the autoimmune microbiome for type 1 diabetes,” ISME Journal, vol. 5, no. 1, pp. 82–91, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. C. T. Brown, A. G. Davis-Richardson, A. Giongo et al., “Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes,” PLoS ONE, vol. 6, no. 10, Article ID e25792, 2011. View at Publisher · View at Google Scholar · View at Scopus