HLA-E: A Novel Player for Histocompatibility

Table 1

HLA-E peptide ligands.

Peptide ligands; (origin)	HLA-E*01:01	HLA-E*01:03	TCR	CD94/NKG2A	Reference
Naturally presented ligands
ALALVRMLI; (ATP binding cassette transporter, MRP7)	ND	ND	ND	+	[18]
VMAPRTLFL; (HLA-G)	+	+	−	+	[33]
VMAPRTLIL; (CMV UL40; HLA-C)	+	+	+	+	[26, 35, 38]
VMAPRTLVL; (CMV; HLA-A)	+	+	+	+	[36, 57]
Predicted ligands
QMRPVSRVL; (human HSP60)	+	+	ND	−	[17]
AISPRTLNA; (HIV Gag protein)	ND	ND	ND	+	[19]
SQQPYLQLQ (gliadin-wheat protein)	ND	ND	ND	+	[20]
SQAPLPCVL; (EBV-BZLF1 protein)	+	+	+	+	[33]

This table shows the diversity of naturally presented or predicted HLA-E peptide ligands and their interactions with immune receptors. Since CD94/NKG2C receptor interactions with HLA-E bound to noncanoncial peptide ligands are poorly reported in the literature, data is not included. +: positive for binding; −: no binding; ND: not determined.