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Journal of Immunology Research
Volume 2014, Article ID 361419, 14 pages
Research Article

In Vivo Inflammatory Effects of Ceria Nanoparticles on CD-1 Mouse: Evaluation by Hematological, Histological, and TEM Analysis

1Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy
2Unitat de Toxicologia Experimental y Ecotoxicologia (UTOX), Parc Cientific de Barcelona, 08028 Barcelona, Spain
3Immunotoxicology and Allergy Unit, Ageing Research Center, University Foundation, Department of Medicine and Science of Ageing, University “D’Annunzio” of Chieti-Pescara, 66100 Chieti, Italy
4Department of Physical and Chemical Sciences, University of L’Aquila, 67100 L’Aquila, Italy

Received 7 May 2014; Accepted 21 May 2014; Published 17 June 2014

Academic Editor: Takemi Otsuki

Copyright © 2014 Anna Poma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The attention on CeO2-NPs environmental and in vivo effects is due to their presence in diesel exhaust and in diesel filters that release a more water-soluble form of ceria NPs, as well as to their use for medical applications. In this work, acute and subacute in vivo toxicity assays demonstrate no lethal effect of these NPs. Anyhow, performing in vivo evaluations on CD-1 mouse systems, we demonstrate that it is even not correct to assert that ceria NPs are harmless for living systems as they can induce status of inflammation, revealed by hematological-chemical-clinical assays as well as histological and TEM microscope observations. TEM analysis showed the presence of NPs in alveolar macrophages. Histological evaluation demonstrated the NPs presence in lungs tissues and this can be explained by assuming their ability to go into the blood stream and lately into the organs (generating inflammation).