Journal of Immunology Research

Clinical Study

Low-Dose Decitabine-Based Chemoimmunotherapy for Patients with Refractory Advanced Solid Tumors: A Phase I/II Report

Table 2

Clinical characteristics of patients.


Subject	Baseline diagnosis	Style of previous therapy	Response to previous therapy	Style of DAC therapy	Response to DAC therapy	PFS to DAC therapy

UPN 1*	Gastric cardia adenocarcinoma	Chemo × 4, TACE × 2	PD	DAC	PD	0
UPN 2	Colorectal adenocarcinoma	Chemo × 10, surgery	PD	DAC	SD	3
UPN 3	Hepatocellular carcinoma	TACE, live transplant	PD	DAC	PD	5
UPN 4*	Gastric cancer	Chemo × 12	PD	DAC	PD	0
UPN 5**	Esophageal adenocarcinoma	Surgery	PD	DAC	SD	5
UPN 6*	Intrahepatic bile ducts adenocarcinoma	Radiation	PD	DAC	PD	2
UPN 7*	Alveolar carcinoma	Chemo × 4, radiation	PD	DAC	PD	1
UPN 8	Malignant pleural tumors	Chemo × 9	PD	DAC	PR	12
UPN 9	Diffuse large B-cell lymphoma	Chemo × 8	PD	DAC + chemo	SD	5
UPN 10*	Non-Hodgkin's lymphoma	Chemo × 5, surgery	PD	DAC + chemo	PD	0
UPN 11*	Non-Hodgkin's lymphoma	Chemo × 25	PD	DAC + chemo	PD	2
UPN 12	Non-Hodgkin's lymphoma	Chemo × 12	PD	DAC + chemo	PD	6
UPN 13*	Non-Hodgkin's lymphoma	Chemo × 9	PD	DAC + chemo	PD	2
UPN 14	Hodgkin's lymphoma	Chemo × 15	PD	DAC + chemo	SD	4
UPN 15	Colon adenocarcinoma	Chemo × 15	PD	DAC + chemo	PD	2
UPN 16	Colorectal cancer	Chemo × 10, gamma knife argon helium knife	PD	DAC + chemo	SD	0
UPN 17	Esophageal squamous cell carcinomas	Chemo × 7, surgery	PD	DAC + chemo	PD	3
UPN 18	Cardia adenocarcinoma	Chemo × 5	PD	DAC + chemo	SD	6
UPN 19**	Small cell carcinoma of the esophagus	Chemo × 8, surgery, and radiation	PD	DAC + chemo	SD	2
UPN 20	Lung adenocarcinoma	Chemo × 3, surgery, and radiation	PD	DAC + chemo	PR	4
UPN 21*	Lung adenocarcinoma	Chemo × 4	PD	DAC + chemo	SD	5
UPN 22*	Lung adenocarcinoma	Chemo × 7	PD	DAC + chemo	SD	4
UPN 23	Lung adenocarcinoma	Chemo × 6, radiation	PD	DAC + chemo	PD	3
UPN 24	Cervical squamous cell carcinomas	Chemo × 10, radiation	PD	DAC + chemo	PD	4
UPN 25	Ovary serous papillary cystadenocarcinoma	Chemo × 28, surgery	PD	DAC + chemo	PR	5
UPN 26	Tubal serous adenocarcinoma	Chemo × 10, surgery	PD	DAC + chemo	SD	7
UPN 27	Pancreatic cancer	Chemo × 9, surgery	PD	DAC + CIK	SD	9
UPN 28	Hepatocellular carcinoma	TACE, radiation	PD	DAC + CIK	SD	5
UPN 29	Hepatocellular carcinoma	Surgery, TACE, and radiation	PD	DAC + CIK	PD	4
UPN 30	Hepatocellular carcinoma	TACE × 6	PD	DAC + CIK	SD	10
UPN 31	Hepatocellular carcinoma	Surgery, TACE × 2	PD	DAC + CIK	SD	8

Note. CIK: cytokine induced killer cells; TACE: transcatheter arterial chemoembolization; DAC + chemo: decitabine in combination with chemotherapy; DAC + CIK: decitabine in combination with CIK; patients died because of disease progression or infection; **patient died from giving up treatment for less than three cycles.