The Expression and Clinical Significance of Different Forms of Mer Receptor Tyrosine Kinase in Systemic Lupus Erythematosus

Table 2

Correlations of the mMer on circulating CD14+ monocytes/macrophages and sMer in plasma with the studied parameters in patients with SLE.

Clinical; manifestations	mMer (MFI)		sMer (pg/mL)
	Spearman’s 𝑟	𝑃 value	Spearman’s 𝑟	𝑃 value
SLEDAI	0.343	0.026*	0.229	0.017*
24 h proteinuria excretion	−0.079	0.621	0.32	0.002**
Hb	0.186	0.238	0.077	0.43
Leucocytes	−0.005	0.976	−0.146	0.132
Thrombocytes	−0.023	0.886	0.01	0.917
Anti-dsDNA Ab	0.043	0.786	0.062	0.525
ACL	−0.101	0.53	0.021	0.83
AnuA	0.214	0.174	0.088	0.366
C3	0.097	0.543	−0.171	0.077*
C4	0.178	0.261	−0.051	0.603
IgA	0.214	0.174	−0.002	0.98
IgG	0.066	0.679	−0.052	0.593
IgM	−0.057	0.722	−0.072	0.463
CRP	0.101	0.523	0.06	0.539

SLE: systemic lupus erythematosus; SLEDAI: systemic lupus erythematosus disease activity index; mMer: membrane Mer tyrosine Kinase; sMer: soluble Mer tyrosine kinase; MFI: mean fluorescence intensity; ANA: antinuclear antibody; Hb: haemoglobin; Anti-dsDNA Ab: Anti-double strand DNA Antibody; ACL: anticardiolipin antibody; AnuA: antinucleosome antibody; C3: Complement component 3; C4: Complement component 4; CRP: C-reactive protein. *𝑃<0.05, **𝑃<0.01. Spearman’s correlation coefficient (𝑟) was applied to detect correlation between two types of numerical data.