Research Article

Evaluation of Diagnostic Value in Using a Panel of Multiple Tumor-Associated Antigens for Immunodiagnosis of Cancer

Table 3

Evaluation of diagnostic values of different TAA panels in the diagnosis of cancer.

    Number of different TAA panelsa
12345678

NHSPositive % (number)0 (0)1.7 (1)1.7 (1)3.4 (2)6.9 (4)8.6 (5)12.1 (7)13.8 (8)

Lung (98)Positive % (number)9.2 (9)20.4 (20)31.6 (31)41.8 (41)48.0 (47)55.1 (54)59.2 (58)64.3 (63)
Se/Sp9.2/100.020.4/98.331.6/98.341.8/96.648.0/93.155.1/91.459.2/87.964.3/86.2
YI0.0920.1870.2990.3840.4110.4650.4710.505
PPV/NPV100.0/39.595.2/42.296.9/46.095.3/49.692.2/51.491.5/54.689.2/56.088.7/58.8

HCC (50)Positive % (number)18.0 (9)34.0 (17)44.0 (22)52.0 (26)54.0 (27)58.0 (29)64.0 (32)66.0 (33)
Se/Sp18.0/100.034.0/98.344.0/98.352.0/96.654.0/93.158.0/91.464.0/87.966.0/86.2
YI0.1800.3230.4230.4860.4710.4940.5200.522
PPV/NPV100.0/58.694.4/63.395.7/67.192.9/70.087.1/70.185.3/71.682.1/73.980.5/74.6

Colorectal (46)Positive % (number)15.2 (7)32.6 (15)43.5 (20)47.8 (22)52.2 (24)54.3 (25)60.9 (28)65.2 (30)
Se/Sp15.2/100.032.6/98.343.5/98.347.8/96.652.2/93.154.3/91.460.9/87.965.2/86.2
YI0.1520.3090.4180.4440.4530.4570.4880.514
PPV/NPV100.0/59.893.8/63.395.2/68.791.7/70.085.7/71.183.3/71.680.0/73.978.9/75.8

Gastric (41)Positive % (number)4.9 (2)14.6 (6)24.4 (10)39.0 (16)46.3 (19)51.2 (21)56.1 (23)56.1 (23)
Se/Sp4.9/100.014.6/98.324.4/98.339.0/96.646.3/93.151.2/91.456.1/87.956.1/86.2
YI0.0490.1290.2270.3560.3940.4260.4400.423
PPV/NPV100.0/59.885.7/62.090.9/64.888.9/69.182.6/71.180.8/72.676.7/73.974.2/73.5

Others (69)Positive % (number)11.6 (8)21.7 (15)26.1 (18)42.0 (29)52.2 (36)55.1 (38)60.9 (42)63.8 (44)
Se/Sp11.6/100.021.7/98.326.1/98.342.0/96.652.2/93.155.1/91.460.9/87.963.8/86.2
YI0.1160.2000.2440.3860.4530.4650.4880.500
PPV/NPV100.0/48.793.8/51.494.7/52.893.5/58.390.0/62.188.4/63.185.7/65.484.6/66.7

Total (304)Positive % (number)11.5 (35)24.0 (73)33.2 (101)44.1 (134)50.3 (153)55.0 (167)60.2 (183)63.5 (193)
Se/Sp11.5/100.024.0/98.333.2/98.344.1/96.650.3/93.155.0/91.460.2/87.963.5/86.2
YI0.1150.2230.3150.4070.4340.4640.4810.497
PPV/NPV100.0/17.798.6/19.899.0/21.998.5/24.897.5/26.397.1/27.996.3/29.796.0/31.1

Number of different TAA panels, corresponding to TAA panels shown in Table 2.
Se: sensitivity; Sp: specificity; YI: Youden’s index; PPV: positive predictive value; NPV: negative predictive value.