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Journal of Immunology Research
Volume 2014, Article ID 513560, 9 pages
Review Article

Immunological Aspects of Acute and Recurrent Herpes Simplex Keratitis

1Chair and Department of Clinical Immunology, Medical University of Lublin, Chodzki 4a, 20-093 Lublin, Poland
2Department of Clinical Transplantology, Medical University of Lublin, Staszica 11, 20-081 Lublin, Poland

Received 25 April 2014; Revised 22 July 2014; Accepted 20 August 2014; Published 7 September 2014

Academic Editor: Boguslaw Machalinski

Copyright © 2014 Jacek Rolinski and Iwona Hus. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Herpes simplex keratitis (HSK) belongs to the major causes of visual morbidity worldwide and available methods of treatment remain unsatisfactory. Primary infection occurs usually early in life and is often asymptomatic. Chronic visual impairment and visual loss are caused by corneal scaring, thinning, and vascularization connected with recurrent HSV infections. The pathogenesis of herpetic keratitis is complex and is still not fully understood. According to the current knowledge, corneal scarring and vascularization are the result of chronic inflammatory reaction against HSV antigens. In this review we discuss the role of innate and adaptive immunities in acute and recurrent HSV ocular infection and present the potential future targets for novel therapeutical options based on immune interventions.