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Journal of Immunology Research
Volume 2014, Article ID 536050, 10 pages
Research Article

Anti-Cyclic Citrullinated Peptide (Anti-CCP) and Anti-Mutated Citrullinated Vimentin (Anti-MCV) Relation with Extra-Articular Manifestations in Rheumatoid Arthritis

1Department of Internal Medicine—Rheumatology, Hospital General Regional 110, IMSS, Avenida Salto del Agua 2192, Colonia Jardines del Country, 44710 Guadalajara, Jal, Mexico
2Postdoctoral Program of the National Council of Science and Technology (CONACYT), 03940 Mexico City DF, Mexico
3Postgraduate Programs of Pharmacology and Public Health Sciences, University Center of Health Sciences (CUCS), University of Guadalajara, 44340 Guadalajara, Jal, Mexico
4Clinical epidemiology Research Unit, UMAE, Specialties Hospital, Western Medical Center, Mexican Institute for Social Security (IMSS), 44340 Guadalajara, Jal, Mexico
5Physiology Department, CUCS, University of Guadalajara Research Division, UMAE, CMNO, IMSS, 44340 Guadalajara, Jal, Mexico
6Department of Physiology, CUCS, University of Guadalajara, 44340 Guadalajara, Jal, Mexico
7Postgraduate Program of Biomedical Sciences (Immunology), CUCS, University of Guadalajara, 44340 Guadalajara, Jal, Mexico

Received 10 January 2014; Revised 21 February 2014; Accepted 2 March 2014; Published 7 April 2014

Academic Editor: Michael Mahler

Copyright © 2014 Laura Gonzalez-Lopez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We evaluated the association between anti-cyclic citrullinated peptide antibodies (anti-CCP) and anti-mutated citrullinated vimentin antibodies (anti-MCV) with the presence of extra-articular (ExRA) manifestations in 225 patients with rheumatoid arthritis (RA). Ninety-five patients had ExRA and 130 had no ExRA. There was no association of anti-CCP and anti-MCV levels with the presence of ExRA as total group ( and , resp.). Making an analysis of individual manifestations, rheumatoid nodules were associated with positivity for rheumatoid factor (RF); (), anti-CCP (), and anti-MCV (). Instead, RF, anti-CCP, or anti-MCV were not associated with SS, chronic anemia, or peripheral neuropathy. Levels of anti-CCP correlated with the score of the Health Assessment Questionnaire-Disability Index (HAQ-Di) (, ), erythrocyte sedimentation rate (ESR); (, ), and RF (, ), whereas anti-MCV titres only correlated with RF (, ). On adjusted analysis, ExRA was associated with longer age (), longer disease duration (), higher DAS-28 score (), and higher HAQ-DI score (), but serum levels of anti-CCP and anti-MCV were not associated. These findings show the need to strengthen the evaluation of the pathogenic mechanisms implied in each specific ExRA manifestation.