Distribution of HLA-A, -B, and -C Alleles and HLA/KIR Combinations in Han Population in China

Table 7

Combination of two inhibitory (KIR2DL2/3 + HLA-C1 and KIR2DL1 + HLA-C2) and two activating (2DS2 + HLA-C1 and 2DS1 + HLA-C2) receptor-ligand pairs in YNH and FYDH.

Number of pairs	KIR/HLA pairs	Yunnan Han (𝑛=239)		FYDH (𝑛=93)		YNH versus FYDH
		𝑁	Frequency	𝑁	Frequency	𝑃 value
Inhibitory or activating
None		3	0.013	0	0.000	0.562
One pair	2DL1 + HLA-C2	5	0.021	1	0.011	1.000
	2DL2/3 + HLA-C1	152	0.636	66	0.710	0.247
	2DS1 + HLA-C2	0	0.000	0	0.000	—
Two pairs	2DL1 + HLA-C2, 2DL2/3 + HLA-C1	42	0.176	19	0.204	0.532
	2DL1 + HLA-C2, 2DS1 + HLA-C2	4	0.017	0	0.000	0.580
	2DL2/3 + HLA-C1, 2DS1 + HLA-C2	0	0.000	1	0.011	0.280
Three pairs	2DL1 + HLA-C2, 2DL2/3 + HLA-C1, 2DS1 + HLA-C2	33	0.138	6	0.065	0.086
Inhibitory
One pair	2DL2/3 + HLA-C1	152	0.636	67	0.720	0.158
	2DL1 + HLA-C2	9	0.038	1	0.011	0.294
Two pairs	2DL1 + HLA-C2, 2DL2/3 + HLA-C1	75	0.314	25	0.269	0.506
None		3	0.013	0	0.000	0.562
Activating
One pair	2DS1 + HLA-C2	37	0.155	7	0.075	0.070
None		202	0.845	86	0.925