Alpha/Beta T-Cell Depleted Grafts as an Immunological Booster to Treat Graft Failure after Hematopoietic Stem Cell Transplantation with HLA-Matched Related and Unrelated Donors

Table 1

Patient characteristics.

Recipient ID	1567	1599	1610	1619	1620
Original HSCT
Sex of recipient	Male	Female	Female	Female	Male
Age of recipient	2	20	59	43	53
HSCT indication	WASP	Sickle cell anemia	Acute myeloid leukemia	Acute lymphoid leukemia	Lymphoma
Serological status; Recipient/donor CMV	+/−	+/+	+/−	−/−	+/+
Serological status; Recipient/donor Toxoplasma	−/−	+/−	+/−	−/−	+/−
Serological status; Recipient/donor EBV	−/+	+/+	+/+	+/+	+/+
Serological status; Recipient/donor HSV1	+/−	−/−	−/+	+/−	−/−
Original graft	BM	BM	BM	BM	PBSC
Preconditioning	RIC	RIC	RIC	MAC	MAC
MUD/related donor	MUD	Sibling	MUD	MUD	MUD
GVHD status	(−)	(−)	(−)	(+)	(+)
Chimerism status prior to; booster	MC	DC	DC	DC	DC
Stem cell booster
Booster indication	Neutropenia; thrombocytopenia	Neutropenia; thrombocytopenia	Neutropenia; thrombocytopenia	Neutropenia; thrombocytopenia	Neutropenia; thrombocytopenia
Infectious problems	CMV	EBV; Mucositis	Toxoplasma	CMV, HSV1	CMV
Source of booster	PBSC	PBSC	BM	PBSC	PBSC
Day of booster	+434	+193	+134	+196	+176
Status 90 days	Alive	Alive	Alive	Alive	Alive
Status 6 months	Alive	Alive	Alive	Deceased	Alive
Response on; leucothrombopenia	(+)	(++)	(++)	(+)	(−)
Response on infectious; complications	(+)	(++)	(+)	(++)	(−)

WASP: Wiskott Aldrich syndrome, MAC: myeloablative conditioning, RIC: reduced intensity conditioning, MC: mixed chimeric, DC: donor chimeric, MUD: matched unrelated donor, GVHD: graft versus host disease (status prior to booster), CMV: cytomegalovirus, EBV: Epstein Barr virus, HSV: herpes simplex virus, PBSC: peripheral blood stem cells, and BM: bone marrow.