Cysteinyl Leukotriene Receptor-1 Antagonists as Modulators of Innate Immune Cell Function

<table>Effects of montelukast, pranlukast, and zafirlukast (0.5 and 1 <i>μ</i>M) on the production of LTB<sub>4</sub> by PAF-activated neutrophils. The results are presented as the mean values for total extracellular LTB<sub>4</sub> (pg/mL) and vertical lines show SEM (<svg height="11.175" id="M12" style="vertical-align:-0.27588pt" version="1.1" viewbox="0 0 36.237499 11.175" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> with 2 replicates for each drug concentration and control system in each experiment). The absolute values for the unstimulated control system and for cells activated were <svg height="11.2875" id="M13" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 42.137501 11.2875" width="42.137501" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> and <svg height="11.4" id="M14" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 82.9375 11.4" width="82.9375" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> pg LTB<sub>4</sub>/mL, respectively. <svg height="13.95" id="M15" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 66.324997 13.95" width="66.324997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> for comparison with the drug-free control system.</table>

Journal of Immunology Research

fig4

Figure 4

Figure 4: Cysteinyl Leukotriene Receptor-1 Antagonists as Modulators of Innate Immune Cell Function 