Cysteinyl Leukotriene Receptor-1 Antagonists as Modulators of Innate Immune Cell Function

Figure 5

Effects of montelukast, pranlukast, and zafirlukast (0.5–20 μM) on cAMP- (a) and cGMP- (b) phosphodiesterase (PDE) activities in neutrophil cytosol. The results are presented as the mean enzyme activities, and vertical lines show SEM (𝑛=2--5, with three to four replicates for each drug concentration and control system in each experiment). ^∗𝑃<0.05 for comparison with the corresponding drug-free control system.

(a)

(b)