Effects of Pristane Alone or Combined with Chloroquine on Macrophage Activation, Oxidative Stress, and Th1/Th2 Skewness
Table 3
The levels of cytokine, IgG2a, IgG1, anti-ds-DNA, anti-Sm, ferritin, fibrinogen, LDH, and triglyceride in serum.
12 wks after treatment
24 wks after treatment
Control
Pristane
Chloroquine
Control
Pristane
IgG2a (mg/mL)
0.61 ± 0.08
5.12 ± 0.71*
4.02 ± 0.93#
0.55 ± 0.04
8.08 ± 1.05*
IgG1 (mg/mL)
0.49 ± 0.02
0.62 ± 0.09
0.53 ± 0.12
0.60 ± 0.06
1.43 ± 0.21*
IgG2a/IgG1
1.21 ± 0.12
8.35 ± 0.07*
7.36 ± 1.06#
0.94 ± 0.05
5.64 ± 0.83*
Anti-ds-DNA (U/mL)
47273 ± 4035
52641 ± 6514
40671 ± 4035#
57003 ± 4583
60460 ± 8353
Anti-Smith (ng/mL)
783 ± 85
4673 ± 647*
1567 ± 205#
865 ± 101
7559 ± 811*
Ferritin (g/L)
865 ± 101
1205.22 ± 47.28*
538.17 ± 50.62#
129.50 ± 37.19
373.22 ± 52.67*
Fibrinogen (mg/mL)
1.52 ± 0.07
1.43 ± 0.21
1.46 ± 0.13
1.57 ± 0.09
1.65 ± 0.27
LDH (IU/L)
279.22 ± 10.9
518.31 ± 34.81*
301.36 ± 42.53#
282.73 ± 32.92
651.22 ± 64.29*
Triglyceride (mmol/L)
0.80 ± 0.07
1.22 ± 0.31*
1.09 ± 0.27
0.91 ± 0.14
0.78 ± 0.09*
TNF- (pg/mL)
104.27 ± 28.83
241.55 ± 31.32*
158.73 ± 30.69#
115.97 ± 21.30
272.00 ± 45.88*
IL-6 (pg/mL)
76.33 ± 18.15
151.78 ± 42.50*
101.84 ± 22.36#
83.77 ± 17.84
291.15 ± 28.93*
IFN- (pg/mL)
59.13 ± 13.92
169.43 ± 32.51*
94.51 ± 11.35#
62.77 ± 11.83
43.89 ± 8.21*
IL-4 (pg/mL)
46.01 ± 7.00
50.23 ± 8.83
43.57 ± 9.31
43.33 ± 7.82
83.11 ± 11.78*
IgG: immunoglobulin G; anti-ds-DNA: double-stranded DNA antibody; LDH: lactate dehydrogenase. Results were expressed as mean ± SE for seven mice. versus the corresponding control mice, versus mice exposure to pristane for 12 weeks.
