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Journal of Immunology Research
Volume 2014, Article ID 686879, 11 pages
http://dx.doi.org/10.1155/2014/686879
Review Article

Immune Escape Mechanisms in Colorectal Cancer Pathogenesis and Liver Metastasis

1Department of Sciences and Technologies, University of Sannio, 82100 Benevento, Italy
2Medical Oncology Unit, Fatebenefratelli Hospital, 82100 Benevento, Italy
3Department of Pathology “Mater Salutis” Hospital, 37045 Legnago (VR), Italy
4Department of Surgery and Oncology, University of Verona, 37129 Verona, Italy
5Bioinformatics Lab, BIOGEM scrl, 83031 Ariano Irpino (AV), Italy

Received 8 September 2013; Revised 18 November 2013; Accepted 18 November 2013; Published 16 January 2014

Academic Editor: Saied Mirshahidi

Copyright © 2014 Massimo Pancione et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Hiroshi Yano, Archana Thakur, Elyse N. Tomaszewski, Minsig Choi, Abhinav Deol, and Lawrence G. Lum, “Ipilimumab augments antitumor activity of bispecific antibody-armed T cells,” Journal of Translational Medicine, vol. 12, 2014. View at Publisher · View at Google Scholar
  • Manik Amin, and Albert Craig Lockhart, “The potential role of immunotherapy to treat colorectal cancer,” Expert Opinion on Investigational Drugs, pp. 1–16, 2014. View at Publisher · View at Google Scholar
  • Annalisa Legitimo, Rita Consolini, Alessandra Failli, Giulia Orsini, and Roberto Spisni, “Dendritic cell defects in the colorectal cancer,” Human Vaccines & Immunotherapeutics, pp. 00–00, 2014. View at Publisher · View at Google Scholar
  • Zhen Zhang, Li-Ping Wang, Xian-Lan Zhao, Fei Wang, Lan Huang, Meng Wang, Xin-Feng Chen, Hong Li, and Yi Zhang, “Pseudomonas aeruginosa injection enhanced antitumor cytotoxicity of cytokine-induced killer cells derived from cord blood,” Biomedicine & Pharmacotherapy, 2014. View at Publisher · View at Google Scholar
  • Achim Krüger, “Premetastatic niche formation in the liver: emerging mechanisms and mouse models,” Journal of Molecular Medicine, 2015. View at Publisher · View at Google Scholar
  • Laura Cartularo, Freda Laulicht, Hong Sun, Thomas Kluz, Jonathan H. Freedman, and Max Costa, “Gene expression and pathway analysis of human hepatocellular carcinoma cells treated with cadmium,” Toxicology and Applied Pharmacology, 2015. View at Publisher · View at Google Scholar
  • Amany Ahmed Abd El-Aal, Ashraf Mohamed Emran, Abeer Said Al-Antably, Enas Ali El Saftawy, Ibrahim R. Bayoumy, Nabila Salah Hassan, and Manal Badawi, “Immunohistochemical pattern of T lymphocytes population within bilharzial-associated bladder neoplasm microenvironment,” International Journal Of Immunopathology And Pharmacology, vol. 28, no. 2, pp. 209–217, 2015. View at Publisher · View at Google Scholar
  • Jonas Heilskov Graversen, and Søren Kragh Moestrup, “Drug trafficking into macrophages via the endocytotic receptor CD163,” Membranes, vol. 5, no. 2, pp. 228–252, 2015. View at Publisher · View at Google Scholar
  • Xia Wang, Xiaoling Ding, Lijuan Nan, Yiting Wang, Jing Wang, Zhiqiang Yan, Wei Zhang, Jihong Sun, Wei Zhu, Bing Ni, Suzhen Dong, and Lei Yu, “Investigation of the roles of exosomes in colorectal cancer liver metastasis,” Oncology Reports, vol. 33, no. 5, pp. 2445–2453, 2015. View at Publisher · View at Google Scholar
  • Bin Zhang, Bin Song, Xin Wang, Xu-Sheng Chang, Tao Pang, Xin Zhang, Kai Yin, and Guo-En Fang, “The expression and clinical significance of CD73 molecule in human rectal adenocarcinoma,” Tumor Biology, 2015. View at Publisher · View at Google Scholar
  • Elena Voronov, and Ron N. Apte, “IL-1 in Colon Inflammation, Colon Carcinogenesis and Invasiveness of Colon Cancer,” Cancer Microenvironment, 2015. View at Publisher · View at Google Scholar
  • Guido Giordano, Antonio Febbraro, Eugenio Tomaselli, Maria Lucia Sarnicola, Pietro Parcesepe, Domenico Parente, Nicola Forte, Alessio Fabozzi, Andrea Remo, Andrea Bonetti, Erminia Manfrin, Somayehsadat Ghasemi, Michele Ceccarelli, Luigi Cerulo, Flavia Bazzoni, and Massimo Pancione, “Cancer-related CD15/FUT4 overexpression decreases benefit to agents targeting EGFR or VEGF acting as a novel RAF-MEK-ERK kinase downstream regulator in metastatic colorectal cancer,” Journal of Experimental & Clinical Cancer Research, vol. 34, no. 1, 2015. View at Publisher · View at Google Scholar
  • Kathryn Heyob, Mehboob Ali, Naduparambil K. Jacob, and Lynette K. Rogers, “Alterative expression and localization of profilin 1/VASPpS157 and cofilin 1/VASPpS239 regulates metastatic growth and is modified by DHA supplementation,” Molecular Cancer Therapeutics, vol. 15, no. 9, pp. 2220–2231, 2016. View at Publisher · View at Google Scholar
  • Ling Li, Jie Yu, Weiqiang Shi, Ke Zhang, Liping Zhang, Jianxin Ye, Yingying Liu, Tingting Xia, Chunhui Jin, and Dongmei Gu, “FOXP3 and CEACAM6 expression and T cell infiltration in the occurrence and development of colon cancer,” Oncology Letters, vol. 11, no. 6, pp. 3693–3701, 2016. View at Publisher · View at Google Scholar
  • Barry Paul, Bert H O'Neil, and Autumn J McRee, “Checkpoint inhibition for colorectal cancer: progress and possibilities,” Immunotherapy, vol. 8, no. 6, pp. 693–704, 2016. View at Publisher · View at Google Scholar
  • Junya Ohtake, Satoshi Wada, Erika Yada, Yuki Fujimoto, Hidemi Uchiyama, Shintaro Yoshida, Kyogo Itoh, and Tetsuro Sasada, “Personalized immunotherapy in colorectal cancer,” Expert Review of Precision Medicine and Drug Development, pp. 1–11, 2016. View at Publisher · View at Google Scholar
  • Elliot Servais, and Scott J. Swanson, “Thoracoscopic Management of Pulmonary Metastases,” Thoracic Surgery Clinics, vol. 26, no. 1, pp. 91–+, 2016. View at Publisher · View at Google Scholar
  • Luca Antonioli, Gennady G. Yegutkin, Pál Pacher, Corrado Blandizzi, and György Haskó, “Anti-CD73 in Cancer Immunotherapy: Awakening New Opportunities,” Trends in Cancer, 2016. View at Publisher · View at Google Scholar
  • Pietro Parcesepe, Guido Giordano, Carmelo Laudanna, Antonio Febbraro, and Massimo Pancione, “Cancer-Associated Immune Resistance and Evasion of Immune Surveillance in Colorectal Cancer,” Gastroenterology Research and Practice, vol. 2016, pp. 1–8, 2016. View at Publisher · View at Google Scholar
  • Agata Olejniczak, Magdalena Szaryńska, and Zbigniew Kmieć, “The role of cancer stem cells in pathogenesis of colorectal cancer,” Postepy Higieny i Medycyny Doswiadczalnej, vol. 70, pp. 1469–1482, 2016. View at Publisher · View at Google Scholar
  • Jian Zhang, Tao Mao, Shuyun Wang, Dongsheng Wang, Zhaojian Niu, Zhenqing Sun, and Jianli Zhang, “Interleukin-35 expression is associated with colon cancer progression.,” Oncotarget, vol. 8, no. 42, pp. 71563–71573, 2017. View at Publisher · View at Google Scholar
  • Niklas K Finnberg, Abbas El-Sayed Abbas, Luigi Grasso, Nicholas C Nicolaides, Wafik S El-Deiry, Prashanth Gokare, Avital Lev, Sergei I Grivennikov, Alexander W MacFarlane, Kerry S Campbell, Ryan M Winters, Karen Kaputa, and Jeffrey M Farma, “Application of 3D tumoroid systems to define immune and cytotoxic therapeutic responses based on tumoroid and tissue slice culture molecular signatures.,” Oncotarget, vol. 8, no. 40, pp. 66747–66757, 2017. View at Publisher · View at Google Scholar
  • Fernand-Pierre Gendron, Morgane Placet, and Guillaume Arguin, “P2Y2 Receptor Functions in Cancer: A Perspective in the Context of Colorectal Cancer,” 2017. View at Publisher · View at Google Scholar
  • Marco C. Merlano, Cristina Granetto, Elena Fea, Vincenzo Ricci, and Ornella Garrone, “Heterogeneity of colon cancer: From bench to bedside,” ESMO Open, vol. 2, no. 3, 2017. View at Publisher · View at Google Scholar
  • Francesca Mion, Stefania Vetrano, Silvia Tonon, Viviana Valeri, Andrea Piontini, Alessia Burocchi, Luciana Petti, Barbara Frossi, Alessandro Gulino, Claudio Tripodo, Mario P. Colombo, and Carlo E. Pucillo, “ Reciprocal influence of B cells and tumor macro and microenvironments in the Apc Min/+ model of colorectal cancer ,” OncoImmunology, pp. 00–00, 2017. View at Publisher · View at Google Scholar
  • Wen-Wen Sun, Zhi-Hong Xu, Peng Lian, Bei-Li Gao, and Jia-An Hu, “Characteristics of circulating tumor cells in organ metastases, prognosis, and T lymphocyte mediated immune response,” OncoTargets and Therapy, vol. 10, pp. 2413–2424, 2017. View at Publisher · View at Google Scholar
  • Rushan Fei, Yuanwei Zhang, Saisai Wang, Tao Xiang, and Wenbin Chen, “α7 nicotinic acetylcholine receptor in tumor-associated macrophages inhibits colorectal cancer metastasis through the JAK2/STAT3 signaling pathway,” Oncology Reports, vol. 38, no. 5, pp. 2619–2628, 2017. View at Publisher · View at Google Scholar
  • Li-Xia Huang, Hui Qiu, Min-Yu Zhong, Dan Dan, Xiao-Mei Yang, and Pei-Zhong Guo, “Combination of capecitabine and ludartin inhibits colon cancer growth in mice,” Tropical Journal of Pharmaceutical Research, vol. 16, no. 11, pp. 2623–2628, 2017. View at Publisher · View at Google Scholar
  • Wei Li, Yuchen Guo, Hua Zhang, Xuan Sun, Suoning Liu, Daguang Wang, Yang Zhang, and Jian Suo, “Colorectal cancer cells suppress CD4+ T cells immunity through canonical wnt signaling,” Oncotarget, vol. 8, no. 9, pp. 15168–15181, 2017. View at Publisher · View at Google Scholar
  • Jian Zhao, Xiaofei Yan, and Rui Zhang, “Interleukin-37 mediates the antitumor activity in colon cancer through β-catenin suppression,” Oncotarget, vol. 8, no. 30, pp. 49064–49075, 2017. View at Publisher · View at Google Scholar
  • Hiroyuki Shinchi, Hiroshi Okumura, Hiroshi Kurahara, Koji Minami, Kosei Maemura, Masahiko Sakoda, Kiyokazu Hiwatashi, Shinichi Ueno, Motoyuki Hashiguchi, Yota Kawasaki, Yuko Mataki, Shoji Natsugoe, and Satoshi Iino, “Prognostic significance of CD68, CD163 and Folate receptor-β positive macrophages in hepatocellular carcinoma,” Experimental and Therapeutic Medicine, vol. 15, no. 5, pp. 4465–4476, 2018. View at Publisher · View at Google Scholar
  • Tatiana A. Karakasheva, George A. Dominguez, Ayumi Hashimoto, Eric W. Lin, Christopher Chiu, Kate Sasser, Jae W. Lee, Gregory L. Beatty, Dmitry I. Gabrilovich, and Anil K. Rustgi, “CD38+ M-MDSC expansion characterizes a subset of advanced colorectal cancer patients,” JCI Insight, vol. 3, no. 6, 2018. View at Publisher · View at Google Scholar
  • Lidia Ruiz-López, Isabel Blancas, José M Garrido, Nuria Mut-Salud, Marta Moya-Jódar, Antonio Osuna, and Fernando Rodríguez-Serrano, “The role of exosomes on colorectal cancer: A review,” Journal of Gastroenterology and Hepatology, 2018. View at Publisher · View at Google Scholar
  • Xuejun Feng, Hongxian Liu, Xiaojie Chu, Pengyan Sun, Weiwei Huang, Cunbao Liu, Xu Yang, Wenjia Sun, Hongmei Bai, and Yanbing Ma, “Recombinant Virus-like Particles Presenting IL-33 Successfully Modify the Tumor Microenvironment and Facilitate Antitumor Immunity in a Model of Breast Cancer,” Acta Biomaterialia, 2019. View at Publisher · View at Google Scholar
  • Andrea Remo, Matteo Fassan, Alessandro Vanoli, Luca Reggiani Bonetti, Valeria Barresi, Fabiana Tatangelo, Roberta Gafà, Guido Giordano, Massimo Pancione, Federica Grillo, and Luca Mastracci, “Morphology and Molecular Features of Rare Colorectal Carcinoma Histotypes,” Cancers, vol. 11, no. 7, pp. 1036, 2019. View at Publisher · View at Google Scholar
  • Weijia Han, and Zhongping Duan, “Roles of exosomes in liver metastases: Novel diagnosis and treatment choices,” Journal of Cellular Physiology, 2019. View at Publisher · View at Google Scholar
  • Shijie Duan, Pengliang Wang, Funan Liu, Hanwei Huang, Wen An, Siwei Pan, and Xin Wang, “Novel immune–risk score of gastric cancer: A molecular prediction model combining the value of immune–risk status and chemosensitivity,” Cancer Medicine, 2019. View at Publisher · View at Google Scholar
  • Jong Lyul Lee, Seon Ae Roh, Chan Wook Kim, Yi Hong Kwon, Ye Jin Ha, Seon-Kyu Kim, Seon-Young Kim, Dong-Hyung Cho, Yong Sung Kim, and Jin Cheon Kim, “Clinical assessment and identification of immuno-oncology markers concerning the 19-gene based risk classifier in stage IV colorectal cancer,” World Journal of Gastroenterology, vol. 25, no. 11, pp. 1341–1354, 2019. View at Publisher · View at Google Scholar
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