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Journal of Immunology Research
Volume 2014, Article ID 738297, 9 pages
Research Article

Factors Affecting Health-Related Quality of Life and Physical Activity after Liver Transplantation for Autoimmune and Nonautoimmune Liver Diseases: A Prospective, Single Centre Study

1Department of Physical Culture and Health Promotion, University of Szczecin, 70 067 Szczecin, Poland
2Liver Research Laboratories, Pomeranian Medical University, 70 111 Szczecin, Poland
3Medical Biology Laboratory, Pomeranian Medical University, 70 111 Szczecin, Poland
4Liver and Internal Medicine Unit, Department of General, Transplant and Liver Surgery of the Medical University of Warsaw 02 097 Warsaw, Poland
5Institute of Liver Studies, Division of Liver Transplantation and Mucosal Biology, King’s College London School of Medicine, Denmark Hill Campus, London SE5 9RS, UK

Received 17 September 2013; Accepted 11 January 2014; Published 4 March 2014

Academic Editor: Eirini I. Rigopoulou

Copyright © 2014 Katarzyna Kotarska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background/Aim. With the improvement of the outcomes after liver transplantation (LTx), health-related quality of life (HRQoL) and physical activity are becoming significant outcome parameters. We prospectively assessed these parameters in patients with autoimmune and nonautoimmune liver disorders undergoing LTx. Materials and Methods. Patients () were subdivided into 3 groups depending on the time after LTx: group-A (): 6–12 months; group-B (): 13–36 months; and group-C (): >37 months. SF-36 and IPAQ were applied in HRQoL and physical activity assessment. Results. Females had impaired HRQoL in most SF-36 domains. Younger patients showed higher scores at SF-36 physical functioning domain but IPAQ was not influenced by age. Group-B had higher general health and physical component summary than group-A (, , resp.) and total IPAQ than group-C (). The sitting time domain was longer in group-A than in group-B and group-C (;  , resp.). Employed patients had better HRQoL and higher physical activity than those not working. SF-36 and IPAQ were unrelated to the autoimmune etiology of liver disease. Conclusions. These findings show that female and unemployed patients have worse HRQoL, while gender and age at LTx time do not affect IPAQ’s physical activity. The autoimmune etiology of liver disease does not influence HRQoL and physical activity after LTx.