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Journal of Immunology Research
Volume 2014, Article ID 762514, 4 pages
http://dx.doi.org/10.1155/2014/762514
Research Article

Association of Helicobacter pylori and iNOS Production by Macrophages and Lymphocytes in the Gastric Mucosa in Chronic Gastritis

FSBI Research Center of Clinical and Experimental Medicine, SB RAMS, Timakova Street 2, Novosibirsk 630117, Russia

Received 17 July 2014; Revised 1 September 2014; Accepted 2 September 2014; Published 18 September 2014

Academic Editor: David B. Ordiz

Copyright © 2014 Lilia A. Cherdantseva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Helicobacter pylori is one of the most common causes of chronic gastritis. With the development of the disease cellular inflammatory infiltrates composed of lymphocytes, plasma cells, and macrophages are formed in epithelium and lamina propria of the stomach. These cells are capable of secreting a number of active substances, including inducible nitric oxide synthase (iNOS). We examined the relationship between H. pylori and secretion of iNOS by cells of inflammatory infiltrates in chronic gastritis by light microscopy and immunohistochemistry. The data obtained indicate that stimulation of H. pylori immune system cells of the host organism during development of chronic gastritis causes increase in number of macrophages and lymphocytes in the inflammatory infiltrate of the gastric mucosa. This is accompanied with increased expression of inducible NO-synthase with excess free radicals in the tissues, which leads to secondary alterations and exacerbates the inflammation with impaired regeneration processes.