Table 3: Top100 values of p1 for positive perturbations in training series.

New experimentExperiment of referenceInput perturbation terms
IDESequencehosoiptqIDESequencehosoiptq

115153MKGVVC
TRIYEKV
Homo sapiens Homo sapiens OAIDELISA115155NNQRK
KAKNTP
FNMLKRERN
Mus musculus Dengue virus 2 AIDWI0.010.0120.0040.0170.012
52124QQQPPHomo sapiens Triticum aestivum OOAELISA52128QQQQGG
SQSQKGKQQ
Homo sapiens Glycine max OOAWI00−0.01800.002
3639APLGVTHomo sapiens Hepatitis E virus EWEIRELISA3652APLTRG
SCRKRN
RSPER
Homo sapiens Human herpesvirus OOIDELISA0.040.040.0390.0430.04
135959LTRAYA
KDVKFG
Homo sapiens Homo sapiens OAIDELISA135963NGQEEK
AGVVS
TGLIGGG
Mus musculus MDAIDELISA−0.04−0.038−0.047−0.033−0.04
108075PREPQVYHomo sapiens Homo sapiens OAIDELISA108078PTSPSGV
EEWIVTQ
VVPGVA
Oryctolagus cuniculus Homo sapiens AIDACAbB−0.01−0.006−0.01−0.003−0.011
25113HVVDLPHomo sapiens Hepatitis E virus EWEIRELISA25126HWGNH
SKSHPQR
Mus musculus MDAIDELISA0.020.0220.0130.0230.02
48780PPFSPQHomo sapiens Hepatitis delta virus OOIDELISA48782PPFTSAV
GGVDHRS
Mus musculus MDAIDSAC0.020.0220.0080.0210.021
40988LYVVAYQAMus musculus Viscum album AIDELISA41004MAARLCC
QLDPARDV
Homo sapiens Hepatitis B virus OOIDELISA0.020.0180.0060.0190.02
50439QDAYNAAGMus musculus Mycobacterium scrofulaceum AIDELISA50445QDCNCSI
YPGHAS
GHRMAWD
Homo sapiens Hepatitis C virus OOIDELISA0.040.0380.0280.0390.04
98849KIPAVFKIDAHomo sapiens Bos taurus DEWEDWI98850KKGSEEE
GDITNPIN
Homo sapiens Arachis hypogaea OOAIFAIH−0.05−0.05−0.053−0.04−0.051
116171TQDQDP
BBHFFK
NIVTPR
Homo sapiens Homo sapiens OAIDACAbB116286CGKGLS
ATVTGG
QKGRGSR
Oryctolagus cuniculus Mus musculus AIDMS0.010.0140.0080.0170.009
123442LLKDLRKNHomo sapiens Borna disease virus EWEIRWI123443LLTEHR
MTWDPA
QPPRDLTE
Homo sapiens Homo sapiens OOIDELISA−0.02−0.02−0.025−0.017−0.022
47858PHVVDLHomo sapiens Hepatitis E virus EWEIRELISA47860PHWIK
KPNRQG
LGYYS
Capra hircus Human T-lymphotropic virus AIDACAbB0.010.0070.0050.0130.009
61783STNKAVVSLSBos taurus Bovine respiratory AIDELISA61792STNPKP
QRKTKRN
TNRRPQD
Homo sapiens Hepatitis C virus OOIDELISA0.030.0250.0190.0290.03
118210VMLYQISEEHomo sapiens Homo sapiens OAIDWI118217VTKYITK
GWKEVH
Oryctolagus cuniculus Homo sapiens AIDELISA0.050.0540.050.0570.048
130944LFKHSOryctolagus cuniculus Rattus norvegicus AIDELISA130956LPPRVTP
KWSLDA
WSTWR
Homo sapiens MDOODWI0.010.006−0.0020.0110.012
23028GVKYAHomo sapiens MDOAIDWI23032GVLAKD
VRFSQV
Homo sapiens MDOOIDELISA0000.007−0.002
51199QKKAIEOryctolagus cuniculus Vibrio cholerae AIDELISA51204QKKNK
RNTNRR
PQDV
Homo sapiens Hepatitis C virus OOIDELISA0.030.0260.0180.0290.03
144783SHVVT
MLDNF
Homo sapiens Homo sapiens NIELISA144786SMNRGRG
THPSLIWM
Mus musculus MDAIDACAbB0.030.0320.0230.0330.029
134343DLYIKMus musculus Human papillomavirus AIDNIAA134344DMAQV
TVGPGLL
GVSTL
Mus musculus Homo sapiens AIDWI00−0.00900
38321LNQLAGRMAnas platyrhynchos Duck hepatitis AIDELISA38323LNQTAR
AFPDCAI
CWEPSPP
Oryctolagus cuniculus Bovine leukemia virus AIDACAbB−0.01−0.008−0.022−0.01−0.011
144657GQITVD
MMYG
Homo sapiens Homo sapiens OAIDELISA144661GREGYP
ADGGCA
WPACYC
Oryctolagus cuniculus MDAIDWI0.020.0240.0130.0270.022
21084GLQNMus musculus Chlamydia trachomatis AIDELISA21093GLRAQD
DFSGWDI
NTPAFEW
Mus musculus Mycobacterium tuberculosis AIDWI0.030.030.0130.030.032
98453SGFSGSVQFVOryctolagus cuniculus Neisseria meningitidis AIDELISA98456SICSNN
PTCWAIC
KRIPNKK
Mus musculus Human respiratory virus AIDIFAIH0.040.0370.0270.040.041
98453SGFSGSVQFVMus musculus Neisseria meningitidis AIDELISA98456SICSNN
PTCWAIC
KRIPNKK
Mus musculus Human respiratory virus AIDIFAIH0.040.040.0270.040.041
107107EAIQPRattus norvegicus Homo sapiens AIDELISA107110EKERRP
SPIGTATLL
Homo sapiens MDOOAELISA0.050.0480.0430.0530.05
110857FTGEAY
SYWSAK
Homo sapiens Mycoplasma penetrans EWEIRELISA110859GEESRIS
LPLPNF
SSLNLRE
Mus musculus Homo sapiens AIDFIA00.002−0.0170.0030.003
36315LGSAYPMus musculus Mycobacterium leprae MDELISA36317LGSGAFG
TIYKG
Mus musculus Avian erythroblastosis virus AIDACAbB0.010.0100.0110.009
122034WNPADRattus norvegicus Torpedo californica AIDELISA122035WNPAD
YGGIKWN
PADYGGIK
Rattus norvegicus MDAIDRIA0.010.010.0010.010.009
25013HVADIDKLIDMus musculus Puumala virus Kazan AIDELISA25021HVAPTH
YVTESDA
SQRVTQL
Homo sapiens Hepatitis C virus OOIDELISA0−0.002−0.014−0.0010
36162LGIHEOryctolagus cuniculus Candida albicans AIDELISA36166LGIMGE
YRGTPRN
QDLYDAA
Mus musculus Human respiratory  virus AIDRIA0−0.003−0.0070−0.001
67253TWEVLHMus musculus Plasmodium vivax AIDELISA67257TWGEN
ETDVLLL
NNTRPPQ
Homo sapiens Hepatitis C virus OOIDACAbB−0.02−0.022−0.027−0.021−0.021
50990QGYRVSSYLPHomo sapiens Hevea brasiliensis OOAWI50998QHEQDR
PTPSPAP
SRPFSVL
Homo sapiens Hepatitis E virus OOIDELISA0.010.01−0.0020.0070.008
100458RDVLQLYAPEMus musculus Bacillus anthracis AIDELISA100462RFSTRY
GNQNGRI
RVLQRFD
Homo sapiens Arachis hypogaea EWEDELISA0.030.0280.0180.030.03
111036TESTFT
GEAYSV
Homo sapiens Mycoplasma penetrans EWEIRELISA111039TGVPID
PAVPDSS
IVPLLES
Bos taurus Bovine papillomavirus AIDELISA0.030.0350.020.0330.03
117919IFIEMEHomo sapiens Homo sapiens OAIDWI117921IGIIDLIE
KRKFNQ
Mus musculus Homo sapiens AIDWI0.030.0320.030.0370.03
7127CTDTDKLFOryctolagus cuniculus Shigella flexneri AIDELISA7128CTDVST
AIHADQL
TPAW
Homo sapiens SARS coronavirus OOIDELISA0.010.006−0.0030.0090.01
112253PGQSPKLHomo sapiens Homo sapiens OAIDELISA112255PIRALV
GDEVELP
CRISPGK
Mus musculus Homo sapiens AIDELISA0.010.0120.010.0170.01
122034WNPADRattus norvegicus Torpedo californica AIDELISA122038WNPDDY
GGVKWNP
DDYGGVK
Rattus norvegicus MDAIDRIA00−0.0090−0.001
131878FLMLVG
GSTL
Homo sapiens Homo sapiens OAIDACAbB131879FLVAHT
RARAPSA
GERARRS
Mus musculus Mus musculus AIDNIAA0.030.0320.0280.0370.033
70664VQVVYDYQHomo sapiens Treponema pallidum OOIDELISA70667VQWMNR
LIAFAFAG
NHVSP
Homo sapiens Hepatitis C virus OOIDELISA0.050.050.0410.050.05
71545VTVHomo sapiens Helicobacter pylori OOIDELISA71559VTVRGGL
RILSPDRK
Homo sapiens Arachis hypogaea OOAWI0.040.040.0320.0430.042
127856TDVRYKDMus musculus Mus musculus AIDACAbB127857TDVRYK
DDMYHFF
CPAIQAQ
Mus musculus Mus musculus AIDPFF0.010.010.010.010.006
112149GVGWIRQHomo sapiens Homo sapiens OAIDELISA112152HHPART
AHYGSLP
QKSHGRT
Homo sapiens Homo sapiens AIDELISA0000.0070
119581FSCSVMHEHomo sapiens Homo sapiens OAIDELISA119582GLQLIQL
INVDEVNQI
Mus musculus Homo sapiens AIDRIA−0.01−0.008−0.01−0.003−0.011
144657GQITVD
MMYG
Homo sapiens Homo sapiens OAIDELISA144659GREGYP
ADGGAA
GYCNTE
Oryctolagus cuniculus MDAIDWI−0.01−0.006−0.017−0.003−0.008
25013HVADI
DKLID
Mus musculus Puumala virus Kazan AIDELISA25022HVAPTH
YVVESDA
SQRVTQV
Homo sapiens Hepatitis C virus OOIDELISA0−0.002−0.014−0.0010
144652GMRGM
KGLVY
Homo sapiens Homo sapiens OAIDELISA144654GPHPTLE
VVPMGRGS
Mus musculus MDAIDELISA−0.02−0.018−0.027−0.013−0.02
104515HDCRPKKIMus musculus La Crosse virus AIDIFAIH104521IGTLKKIL
DETVKD
KIAKEQ
Rattus norvegicus Streptococcus pyogenes AIDELISA−0.04−0.04−0.053−0.04−0.041
7367CYGDWAHomo sapiens Triticum aestivum OOAELISA7374CYGLPDS
EPTKTNGK
Mus musculus Tityus serrulatus AIDWI−0.02−0.018−0.043−0.023−0.018
7367CYGDWAHomo sapiens Triticum aestivum OOAELISA7374CYGLPDS
EPTKTNGK
Mus musculus Tityus serrulatus AIDWI−0.02−0.018−0.043−0.023−0.018
144610DFFTYKMus musculus Porcine transmissible AIDWI144611DFNGSF
DMNGTITA
Oryctolagus cuniculus Escherichia coli AIDELISA−0.01−0.007−0.018−0.01−0.012
112047ASTRESGHomo sapiens Homo sapiens OAIDELISA112048ATASTM
DHARHGF
LPRHRDT
Homo sapiens Homo sapiens AIDELISA0.050.050.050.0570.05
36136LGGVFTHomo sapiens Dengue virus 2 OOIDELISA36137LGGWKLQ
SDPRAYAL
Homo sapiens Ambrosia artemisiifolia OOARIA0.010.010.0070.0130.009
115256FRELKD
LKGY
Homo sapiens Bos taurus DEWEDWI115261GDLEILL
QKWENG
ECAQKKI
Homo sapiens Bos taurus OOAFIA−0.01−0.01−0.010−0.009
129024KADQLYKHomo sapiens Homo sapiens OAIDELISA129026KAKKP
AAAAGA
KKAKS
Oryctolagus cuniculus Homo sapiens AIDELISA0.030.0340.030.0370.03
148481YTRDLVYKRattus norvegicus Homo sapiens AIDWI148483YVPIVT
FYSEISM
HSSRAIP
Oryctolagus cuniculus MDAIDELISA00.002−0.0070−0.002
150850GYMus musculus Human papillomavirus AIDELISA150853HIGGLSI
LDPIFGVL
Homo sapiens Dermatophagoides farinae OOAACAbB0.040.0380.040.0430.039
107366FPPKPKDHomo sapiens Homo sapiens OAIDELISA107376GDRSGYS
SPGSPG
Mus musculus Homo sapiens AIDACAbB−0.03−0.028−0.03−0.023−0.031
114859ICGTD
GVTYT
Homo sapiens Gallus gallus OOAWI114865IVERETR
GQSENPL
WHALRR
Rattus norvegicus Human herpesvirus AIDELISA0.040.0420.0350.0370.038
62149SVHLFHomo sapiens MDOAIDWI62150SVIALGS
QEGALHQ
ALAGAI
Equus caballus West Nile virus AIDIFAIH−0.02−0.021−0.012−0.013−0.021
98455SGSVQFVPIQMus musculus Neisseria meningitidis AIDELISA98456SICSNNP
TCWAICK
RIPNKK
Mus musculus Human respiratory  virus AIDIFAIH0.040.040.0270.040.041
61783STNKAV
VSLS
Bos taurus Bovine respiratory AIDELISA61791STNPKPQ
RKTKRNT
NRRPQ
Homo sapiens Hepatitis C virus EWEIRACAbB0.040.0350.0290.0370.039
100318NAPKT
FQFIN
Mus musculus Bacillus anthracis AIDELISA100319NASSELH
LLGFGIN
AENNHR
Homo sapiens Arachis hypogaea EWEDELISA0−0.002−0.01200
118947PFSAPPPAHomo sapiens Homo sapiens OAIDELISA118948PGAIEQG
PADDPGE
GPSTGP
Homo sapiens Human herpesvirus NIACAbB−0.04−0.04−0.041−0.036−0.041
78323YSFRDMus musculus Bluetongue virus 1 AIDELISA78341AALTAEN
TAIKKRN
ADAKA
Homo sapiens Streptococcus mutans EEEELISA0.010.0080.0070.0130.01
145831IPLGTRPMus musculus Human papillomavirus AIDELISA145841KEDFRY
AISSTNEI
GLLGA
Sus scrofa Classical swine AIDPAC−0.04−0.04−0.045−0.04−0.043
119592HTFPAVLQHomo sapiens Homo sapiens OAIDELISA119596IHIPSEKI
WRPDLVLY
Mus musculus Homo sapiens AIDRIA0.010.0120.010.0170.009
58780SKAANLSIIKMDBeet necrotic MDWI58783SKAFSN
CYPYDVP
DYASL
Oryctolagus cuniculus Influenza A virus AIDRIA−0.01−0.004−0.014−0.009−0.013
115153MKGVVC
TRIYEKV
Homo sapiens Homo sapiens NIELISA115155NNQRKK
AKNTPFN
MLKRERN
Mus musculus Dengue virus 2 AIDELISA0.010.0120.0040.0130.01
133629LPLRFOryctolagus cuniculus Gallus gallus AIDACAbB133630LPPGLHV
FPLASNRS
Mus musculus MDAIDSPR−0.01−0.013−0.021−0.01−0.01
96215EEEEAE
DKED
Homo sapiens Homo sapiens OAIDELISA96216EEEGLLK
KSADTLW
NMQK
Mus musculus Mus musculus AIDELISA0.080.0820.0780.0870.08
39782LTAASVHomo sapiens Triticum aestivum OOAELISA39788LTAELKI
YSVIQAEI
NKHL
Oryctolagus cuniculus Yersinia pestis AIDACAbB0.010.014−0.0010.0070.009
107479KFNWYVDHomo sapiens Homo sapiens OAIDELISA107482KGEPGL
PGRGFP
GFP
Mus musculus Homo sapiens AIDACAbB00.00200.007−0.001
63569TETVNSDIMacaca mulatta Shigella flexneri AIDELISA63573TEVELKER
KHRIEDAV
RNAK
Homo sapiens Mycobacterium leprae OOIDELISA0.050.0360.0410.0490.05
134028DDTISMus musculus Homo sapiens AIDNIAA134029DEDENQS
PRSFQKKTR
Oryctolagus cuniculus Homo sapiens AIDELISA0.050.0530.050.050.048
23028GVKYAHomo sapiens MDOAIDWI23032GVLAKDV
RFSQV
Homo sapiens MDEWEIRACAbB0000.004−0.003
115293IMCVKK
ILDK
Homo sapiens Bos taurus DEWEDWI115295INPSKEN
LCSTFCK
EVVRNA
Homo sapiens Bos taurus OOAFIA−0.03−0.03−0.03−0.02−0.029
65105TLTPENTLMus musculus Shigella flexneri AIDELISA65110TLTSGSD
LDRCTT
FDDV
Oryctolagus cuniculus SARS coronavirus AIDELISA0.010.013−0.0030.010.01
134471PKPEQMus musculus Streptococcus pneumoniae AIDFACS134472PLLPGT
STTSTG
PCKT
Homo sapiens Hepatitis B virus AIDELISA0.020.0180.0190.020.016
142228LYCYEQ
LNDSSE
Homo sapiens Human papillomavirus NIELISA142250NWGDEP
SKRRDRS
NSRGRKN
Felis catus Feline infectious AIDELISA0.070.0680.0710.0730.07
21549GNYDFW
YQS
Homo sapiens Staphylococcus aureus OOIDELISA21553GNYNYKY
RYLRHGK
LRPFER
Mus musculus SARS coronavirus AIDELISA0.030.0320.0210.0310.03
21549GNYDFWYQSHomo sapiens Staphylococcus aureus OOIDELISA21553GNYNYKY
RYLRHGK
LRPFER
Oryctolagus cuniculus SARS coronavirus AIDELISA0.030.0340.0210.0310.03
34908LAPLGEHomo sapiens Hepatitis E virus EWEIRELISA34914LAPSTL
RSLRKR
RLSSP
Homo sapiens Human herpesvirus OOIDELISA0.060.060.0590.0630.06
130454CLFPNNSYCMus musculus MDAIDNIAA130456CRPQVN
NPKEWS
CAAC
Homo sapiens MDOODACAbB0.010.0080.010.0110.007
19644GFVPSMHomo sapiens Hepatitis delta virus OOIDELISA19647GFVSASI
FGFQAEV
GPNNTR
Oryctolagus cuniculus Vaccinia virus WR AIDELISA−0.01−0.006−0.013−0.009−0.01
20678GKRPEMus musculus Streptococcus pyogenes AIDWI20680GKSKRD
AKNNAAK
LAVDKLL
Mus musculus Vaccinia virus WR AIDWI0.010.010.0010.010.01
123278GYLKDLPTTOvis aries Fasciola hepatica AIDELISA123282HACQKK
LLKFEAL
QQEEGEE
Rattus norvegicus Gallus gallus AIDPFF−0.02−0.016−0.016−0.02−0.025
141067PLSLEPDPMus musculus Homo sapiens AIDFACS141073REGVRW
RVMAIQ
Mus musculus Homo sapiens AIDELISA0.060.060.060.060.056
139248SFAGTVIEMus musculus Classical swine AIDWI139305TAAQITQ
RKWEAA
REAEQRR
Oryctolagus cuniculus Homo sapiens AIDIP0.030.0330.0260.030.03
104515HDCRPKKIMus musculus La Crosse virus AIDIFAIH104520IAKEQE
NKETIGT
LKKILDE
Rattus norvegicus Streptococcus pyogenes AIDELISA−0.06−0.06−0.073−0.06−0.061
113517HLYADGLTDMus musculus Human papillomavirus AIDIFAIH113518HNKIQA
IELEDLLR
YSKLYR
Mus musculus Homo sapiens AIDELISA0.020.020.0110.020.019
156970VERHQHomo sapiens Homo sapiens OAIDELISA156975WSSTV
LRVSPT
RTVP
Mus musculus MDAIDELISA0.010.0120.0030.0170.01
78252PVQNLTMus musculus Porphyromonas gingivalis AIDWI78253QGGCGR
GWAFSA
TGAIEA
Mus musculus Glycine max AIDELISA0.020.020.0170.020.018
6068CCPDKNKSMus musculus Human herpesvirus AIDWI6074CCRHKQ
KDVGDVK
QTLPPS
Ovis aries MDAIDELISA0.010.0060.0040.010.008
53109RAGVCYHomo sapiens Triticum aestivum OOAELISA53116 RAILTA
FSPAQDI
WGTS
Oryctolagus cuniculus SARS coronavirus AIDELISA−0.02−0.016−0.037−0.023−0.02
147041IPEQHomo sapiens Triticum aestivum OOAWI147064KHQGA
QYVWN
RTA
Homo sapiens Bos taurus OOIDWI0.060.060.0470.0570.06
70664VQVVYDYQOryctolagus cuniculus Treponema pallidum AIDELISA70667VQWMN
RLIAFAF
AGNHVSP
Homo sapiens Hepatitis C virus OOIDELISA0.050.0460.0410.0490.05
134343DLYIKMus musculus Human papillomavirus AIDPhDIP134344DMAQV
TVGPGLL
GVSTL
Mus musculus Homo sapiens AIDPhDIP00−0.00900