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Journal of Immunology Research
Volume 2014, Article ID 793817, 7 pages
Review Article

Photobacteriosis: Prevention and Diagnosis

Department of Biomolecular Science, Biotechnology Section, University of Urbino “Carlo Bo”, Via Arco d’Augusto 2, 61032 Fano, Italy

Received 23 December 2013; Accepted 9 May 2014; Published 28 May 2014

Academic Editor: Yong-Suk Jang

Copyright © 2014 Francesca Andreoni and Mauro Magnani. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Photobacteriosis or fish pasteurellosis is a bacterial disease affecting wild and farm fish. Its etiological agent, the gram negative bacterium Photobacterium damselae subsp. piscicida, is responsible for important economic losses in cultured fish worldwide, in particular in Mediterranean countries and Japan. Efforts have been focused on gaining a better understanding of the biology of the pathogenic microorganism and its natural hosts with the aim of developing effective vaccination strategies and diagnostic tools to control the disease. Conventional vaccinology has thus far yielded unsatisfactory results, and recombinant technology has been applied to identify new antigen candidates for the development of subunit vaccines. Furthermore, molecular methods represent an improvement over classical microbiological techniques for the identification of P. damselae subsp. piscicida and the diagnosis of the disease. The complete sequencing, annotation, and analysis of the pathogen genome will provide insights into the pathogen laying the groundwork for the development of vaccines and diagnostic methods.