Efficacy of Primate Humoral Passive Transfer in a Murine Model of Pneumonic Plague Is Mouse Strain-Dependent
Figure 1
Pharmacokinetics of human or cynomolgus macaque antibody in BALB/c and Hsd:NIHS mice, respectively. 0.25 mL human ((a) and (c)) or cynomolgus macaque ((b) and (d)) plague vaccine serum was injected via the intraperitoneal route into BALB/c () or Hsd:NIHS () mice, respectively. The mice were serially sacrificed and the presence of anti-rF1 ((a) and (b)) or anti-rV ((c) and (d)) antibody was assessed by ELISA. Additional groups of mice () were sacrificed preinjection to provide baseline data. The data suggests that the time delay between passive antibody administration and optimal serum concentration in the murine serum was between 3 and 6 hours. a.u., arbitrary units.
