Chinese SLE Treatment and Research Group Registry: III. Association of Autoantibodies with Clinical Manifestations in Chinese Patients with Systemic Lupus Erythematosus

Table 5

Associations with statistical significance between specific autoantibodies and clinical manifestations in SLE patients.

Author	Number of patients	Geographical area	Anti-dsDNA	Anti-Sm	Anti-RNP	Anti-SSA	Anti-SSB	Anti-rRNP	APL
Chien et al.; [13]	80	Asia, China	Raynaud’s; phenomenon; Photosensitivity; Arthritis; Thrombocytopenia; Hypocomplementemia; Proteinuria; Serositis			Photosensitivity; Anemia
McClain et al.; [28]	130	United states							Malar rash; discoid lesions; photosensitivity; renal disorder; neurological; disorder; hemolytic anemia; thrombocytopenia
Vila et al.; [24]	201	Puerto Ricans	Vasculitis; Pericardial effusion; Renal involvement; Anaemia; Leukocytopenia; Lymphocytopenia; Thrombocytopenia	Skin ulcerations; Elevated liver; enzymes; Renal involvement; Thrombocytopenia		Discoid rash; Serositis; Pneumonitis; Elevated liver; enzymes; Hemolytic; anaemia; Leukocytopenia; Lymphocytopenia
Hoffman et al.; [6]	289	Europe, Belgium	Urine cellular casts		Raynaud’s; phenomenon; Leukocytopenia	Xerostomia	Xerostomia; Pericarditis
Tang et al.; [7]	917	Asia, China	Renal disorder; Leukocytopenia; Anemia	Malar rash; Discoid rash; Pericarditis; Leukocytopenia	Raynaud’s; phenomenon; Photosensitivity
Lu et al.; [12]	1803	United states	Renal disease; Urine cellular casts	Leukocytopenia		Hematological; disorder; Lymphocytopenia	Hematological; disorder; Proteinuria; Malar rash
CSTAR	2104	Asia, China	Photosensitivity; Nephropathy	Malar rash	PAH	Nephropathy; PAH	Hematological; disorder	Malar rash	Oral ulceration; hematological; disorder; ILD

ANA: Anti-nuclear antibody; Anti-dsDNA: Anti-double stranded DNA antibody; Anti-Sm: Anti-Sm antibody; Anti-SSA: Anti-SSA antibody; Anti-SSB: Anti-SSB antibody; Anti-RNP: Anti-u1 small-nuclear RNA-protein antibody; Anti-Rrnp: Anti-ribosomal RNA-protein antibody; APL: Anti-phospholipid antibody; PAH: pulmonary arterial hypertension; ILD: interstitial lung disease.