Research Article

Autoantibody Response to Murine Double Minute 2 Protein in Immunodiagnosis of Hepatocellular Carcinoma

Figure 5

Expression of MDM2 in liver cancer and normal hepatic tissues by immunohistochemistry. The polyclonal anti-MDM2 antibody was used as primary antibody to detect the expression of MDM2 in liver cancer and normal hepatic tissues. (a) A normal hepatic tissue had negative staining; (b) HCC tissue (Grade II) had positive staining; (c) HCC tissue (Grade III) had positive staining; (d) a normal hepatic tissue with HE staining; (e) HCC tissue (Grade II) with HE staining; (f) HCC tissue (Grade III) with HE staining. Grade II: moderately differentiated, cells appear slightly different from normal. Grade III: poorly differentiated, cells appear abnormal and tend to grow and spread more aggressively.
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