Journal of Immunology Research / 2014 / Article / Tab 3

Research Article

CD8+ TIL Recruitment May Revert the Association of MAGE A3 with Aggressive Features in Thyroid Tumors

Table 3

Immunohistochemical expression of MAGE A3 and CD8 TIL, according to clinicopathological features of aggressiveness and patient’s outcome.

Clinicopathological featuresSemiquantitative analysis (visual) value*
MAGE A3+ CD8+
(%)
MAGE A3+ CD8− 
(%)

Age
45 years old48 (29%)42 (25%)0.0422
 >45 years old28 (17%)48 (29%)
Tumor size
 <2 cm49 (35%)18 (13%)0.0034
 >2 cm36 (25%)39 (27%)
Extrathyroidal invasion
 Yes39 (27%)38 (27%)0.0427
 No44 (31%)21 (15%)
Capsulation
 Yes18 (14%)23 (17%)0.0875
 No56 (42%)35 (27%)
Multifocality
 Yes34 (25%)22 (16%)0.8585
 No51 (37%)30 (22%)
Metastasis at diagnosis
 Present 53 (38%)39 (28%)0.2719
 Absent32 (23%)15 (11%)
Disease stage (TNM)
 I57 (36%)27 (18%)0.0464
 II4 (3%)6 (4%)
 III8 (5%)10 (7%)
 IV17 (13%)21 (14%)
Outcome
 Free of disease 68 (48%)54 (37%)0.0634
 Recurrent 7 (5%)(10%)

Fisher’s exact test.

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