CD8+ TIL Recruitment May Revert the Association of MAGE A3 with Aggressive Features in Thyroid Tumors

Table 3

Immunohistochemical expression of MAGE A3 and CD8 TIL, according to clinicopathological features of aggressiveness and patient’s outcome.

Clinicopathological features	Semiquantitative analysis (visual)		value^*
	MAGE A3+ CD8+; (%)	MAGE A3+ CD8−; (%)
Age
45 years old	48 (29%)	42 (25%)	0.0422
>45 years old	28 (17%)	48 (29%)
Tumor size
<2 cm	49 (35%)	18 (13%)	0.0034
>2 cm	36 (25%)	39 (27%)
Extrathyroidal invasion
Yes	39 (27%)	38 (27%)	0.0427
No	44 (31%)	21 (15%)
Capsulation
Yes	18 (14%)	23 (17%)	0.0875
No	56 (42%)	35 (27%)
Multifocality
Yes	34 (25%)	22 (16%)	0.8585
No	51 (37%)	30 (22%)
Metastasis at diagnosis
Present	53 (38%)	39 (28%)	0.2719
Absent	32 (23%)	15 (11%)
Disease stage (TNM)
I	57 (36%)	27 (18%)	0.0464
II	4 (3%)	6 (4%)
III	8 (5%)	10 (7%)
IV	17 (13%)	21 (14%)
Outcome
Free of disease	68 (48%)	54 (37%)	0.0634
Recurrent	7 (5%)	(10%)

Fisher’s exact test.