Table of Contents Author Guidelines Submit a Manuscript
Journal of Immunology Research
Volume 2014 (2014), Article ID 962871, 8 pages
http://dx.doi.org/10.1155/2014/962871
Review Article

Significance of Persistent Inflammation in Respiratory Disorders Induced by Nanoparticles

1Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan
2Laboratory of Vaccine Science, WPI Immunology Frontier Research Center, Osaka University, Japan

Received 22 February 2014; Revised 17 June 2014; Accepted 20 June 2014; Published 7 July 2014

Academic Editor: Mario Di Gioacchino

Copyright © 2014 Yasuo Morimoto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. J. A. Borm and K. Driscoll, “Particles, inflammation and respiratory tract carcinogenesis,” Toxicology Letters, vol. 88, no. 1–3, pp. 109–113, 1996. View at Publisher · View at Google Scholar · View at Scopus
  2. E. Shacter and S. A. Weitzman, “Chronic inflammation and cancer.,” Oncology, vol. 16, no. 2, pp. 217–232, 2002. View at Google Scholar · View at Scopus
  3. T. R. Quinlan, K. A. BeruBe, J. P. Marsh et al., “Patterns of inflammation, cell proliferation, and related gene expression in lung after inhalation of chrysotile asbestos,” The American Journal of Pathology, vol. 147, no. 3, pp. 728–739, 1995. View at Google Scholar · View at Scopus
  4. T. Kajiwara, A. Ogami, H. Yamato, T. Oyabu, Y. Morimoto, and I. Tanaka, “Effect of particle size of intratracheally instilled crystalline silica on pulmonary inflammation,” Journal of Occupational Health, vol. 49, no. 2, pp. 88–94, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. Y. Morimoto, A. Ogami, M. Todoroki et al., “Expression of inflammation-related cytokines following intratracheal instillation of nickel oxide nanoparticles,” Nanotoxicology, vol. 4, no. 2, pp. 161–176, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Nishi, Y. Morimoto, A. Ogami et al., “Expression of cytokine-induced neutrophil chemoattractant in rat lungs by intratracheal instillation of nickel oxide nanoparticles,” Inhalation Toxicology, vol. 21, no. 12, pp. 1030–1039, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. K. Fujita, Y. Morimoto, A. Ogami et al., “A gene expression profiling approach to study the influence of ultrafine particles on rat lungs,” in Atmospheric and Biological Environmental Monitoring, J. Y. Kim, U. Platt, M. B. Gu, and H. Iwahashi, Eds., pp. 219–227, Springer, Dordrecht, The Netherlands, 2009. View at Publisher · View at Google Scholar
  8. S. Yokota, T. Seki, M. Furuya, and N. Ohara, “Acute functional enhancement of circulatory neutrophils after intratracheal instillation with diesel exhaust particles in rats,” Inhalation Toxicology, vol. 17, no. 12, pp. 671–679, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. Y. Morimoto, M. Hirohashi, A. Ogami et al., “Inflammogenic effect of well-characterized fullerenes in inhalation and intratracheal instillation studies,” Particle and Fibre Toxicology, vol. 7, article 4, 2010. View at Publisher · View at Google Scholar
  10. Y. Morimoto, M. Hirohashi, M. Horie et al., “Expression of cytokine-induced neutrophil chemoattractant in rat lungs following an intratracheal instillation of micron-sized nickel oxide nanoparticle agglomerates,” Toxicology and Industrial Health. In Press.
  11. F. Shibata, K. Konishi, and H. Nakagawa, “Identification of a common receptor for three types of rat cytokine-induced neutrophil chemoattractants (CINCS),” Cytokine, vol. 12, no. 9, pp. 1368–1373, 2000. View at Publisher · View at Google Scholar · View at Scopus
  12. K. P. Lee, H. J. Trochimowicz, and C. F. Reinhardt, “Pulmonary response of rats exposed to titanium dioxide (TiO2) by inhalation for two years,” Toxicology and Applied Pharmacology, vol. 79, no. 2, pp. 179–192, 1985. View at Publisher · View at Google Scholar · View at Scopus
  13. E. Bermudez, J. B. Mangum, B. A. Wong et al., “Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles,” Toxicological Sciences, vol. 77, no. 2, pp. 347–357, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. T. Oyabu, Y. Morimoto, M. Hirohashi et al., “Dose-dependent pulmonary response of well-dispersed titanium dioxide nanoparticles following intratracheal instillation,” Journal of Nanoparticle Research, vol. 15, no. 4, article 1600, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Morimoto, M. Horie, N. Kobayashi, N. Shinohara, and M. Shimada, “Inhalation toxicity assessment of carbon-based nanoparticles,” Accounts of Chemical Research, vol. 46, no. 3, pp. 770–781, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. N. Kobayashi, M. Naya, S. Endoh, J. Maru, K. Yamamoto, and J. Nakanishi, “Comparative pulmonary toxicity study of nano-TiO2 particles of different sizes and agglomerations in rats: different short- and long-term post-instillation results,” Toxicology, vol. 264, no. 1-2, pp. 110–118, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Ogami, Y. Morimoto, T. Myojo et al., “Histopathological changes in rat lung following intratracheal instillation of silicon carbide whiskers and potassium octatitanate whiskers,” Inhalation Toxicology, vol. 19, no. 9, pp. 753–758, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. R. Sellamuthu, C. Umbright, J. R. Roberts et al., “Blood gene expression profiling detects silica exposure and toxicity,” Toxicological Sciences, vol. 122, no. 2, pp. 253–264, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. R. J. Langley, R. Kalra, N. C. Mishra et al., “A biphasic response to silica. I. Immunostimulation is restricted to the early stage of silicosis in lewis rats,” The American Journal of Respiratory Cell and Molecular Biology, vol. 30, no. 6, pp. 823–829, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. D. Hanahan and R. A. Weinberg, “The hallmarks of cancer,” Cell, vol. 100, no. 1, pp. 57–70, 2000. View at Publisher · View at Google Scholar · View at Scopus
  21. D. Hanahan and R. A. Weinberg, “Hallmarks of cancer: the next generation,” Cell, vol. 144, no. 5, pp. 646–674, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Xu, D. B. Alexander, M. Futakuchi et al., “Size- and shape-dependent pleural translocation, deposition, fibrogenesis and mesothelial proliferation by multi-walled carbon nanotubes,” Cancer Science, 2014. View at Publisher · View at Google Scholar
  23. K. Verstraete and S. N. Savvides, “Extracellular assembly and activation principles of oncogenic class III receptor tyrosine kinases,” Nature Reviews Cancer, vol. 12, no. 11, pp. 753–766, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. H. Li, Y. Pan, Y. Li et al., “Frequency of well-identified oncogenic driver mutations in lung adenocarcinoma of smokers varies with histological subtypes and graduated smoking dose,” Lung Cancer, vol. 79, no. 1, pp. 8–13, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. C. Li, R. Fang, Y. Sun et al., “Spectrum of oncogenic driver mutations in lung adenocarcinomas from East Asian never smokers,” PLoS ONE, vol. 6, no. 11, Article ID e28204, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. K. H. Yi, J. Axtmayer, J. P. Gustin, A. Rajpurohit, and J. Lauring, “Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine,” Oncotarget, vol. 4, no. 1, pp. 29–34, 2013. View at Google Scholar · View at Scopus
  27. M. Zheng, J. Jiang, Y. Tang, and X. Liang, “Oncogene and non-oncogene addiction in inflammation-associated cancers,” Future Oncology, vol. 9, no. 4, pp. 561–573, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Roursgaard, S. S. Poulsen, L. K. Poulsen et al., “Time-response relationship of nano and micro particle induced lung inflammation. Quartz as reference compound,” Human & Experimental Toxicology, vol. 29, no. 11, pp. 915–933, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. E.-J. Park, J. Yoon, K. Choi, J. Yi, and K. Park, “Induction of chronic inflammation in mice treated with titanium dioxide nanoparticles by intratracheal instillation,” Toxicology, vol. 260, no. 1–3, pp. 37–46, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. C. M. Ardies, “Inflammation as cause for scar cancers of the lung,” Integrative Cancer Therapies, vol. 2, no. 3, pp. 238–246, 2003. View at Publisher · View at Google Scholar · View at Scopus
  31. R. J. Reiter, D. Tan, L. C. Manchester, and W. Qi, “Biochemical reactivity of melatonin with reactive oxygen and nitrogen species: a review of the evidence,” Cell Biochemistry and Biophysics, vol. 34, no. 2, pp. 237–256, 2001. View at Publisher · View at Google Scholar · View at Scopus
  32. C. Jin, Y. Tang, F. G. Yang et al., “Cellular toxicity of TiO2 nanoparticles in anatase and rutile crystal phase,” Biological Trace Element Research, vol. 141, no. 1–3, pp. 3–15, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. I. Fenoglio, L. Prandi, M. Tomatis, and B. Fubini, “Free radical generation in the toxicity of inhaled mineral particles: the role of iron speciation at the surface of asbestos and silica,” Redox Report, vol. 6, no. 4, pp. 235–241, 2001. View at Publisher · View at Google Scholar · View at Scopus
  34. A. Manke, L. Wang, and Y. Rojanasakul, “Mechanisms of nanoparticle-induced oxidative stress and toxicity,” BioMed Research International, vol. 2013, Article ID 942916, 15 pages, 2013. View at Publisher · View at Google Scholar
  35. A. Valavanidis, T. Vlachogianni, and C. Fiotakis, “8-Hydroxy-2′ -deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis,” Journal of Environmental Science and Health C: Environmental Carcinogenesis and Ecotoxicology Reviews, vol. 27, no. 2, pp. 120–139, 2009. View at Publisher · View at Google Scholar · View at Scopus
  36. K. Kaneko, T. Akuta, T. Sawa et al., “Mutagenicity of 8-nitroguanosine, a product of nitrative nucleoside modification by reactive nitrogen oxides, in mammalian cells,” Cancer Letters, vol. 262, no. 2, pp. 239–247, 2008. View at Publisher · View at Google Scholar · View at Scopus
  37. F. Guo, N. Ma, Y. Horibe, S. Kawanishi, M. Murata, and Y. Hiraku, “Nitrative DNA damage induced by multi-walled carbon nanotube via endocytosis in human lung epithelial cells,” Toxicology and Applied Pharmacology, vol. 260, no. 2, pp. 183–192, 2012. View at Publisher · View at Google Scholar · View at Scopus
  38. B. Trouiller, R. Reliene, A. Westbrook, P. Solaimani, and R. H. Schiestl, “Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice,” Cancer Research, vol. 69, no. 22, pp. 8784–8789, 2009. View at Publisher · View at Google Scholar · View at Scopus
  39. M. Song, Y. Li, H. Kasai, and K. Kawai, “Metal nanoparticle-induced micronuclei and oxidative DNA damage in mice,” Journal of Clinical Biochemistry and Nutrition, vol. 50, no. 3, pp. 211–216, 2012. View at Publisher · View at Google Scholar · View at Scopus
  40. K. Yoo, C. Yoon, D. Kwon et al., “Titanium dioxide induces apoptotic cell death through reactive oxygen species-mediated Fas upregulation and Bax activation,” International Journal of Nanomedicine, vol. 7, pp. 1203–1214, 2012. View at Publisher · View at Google Scholar · View at Scopus
  41. T. Morishige, Y. Yoshioka, A. Tanabe et al., “Titanium dioxide induces different levels of IL-1β production dependent on its particle characteristics through caspase-1 activation mediated by reactive oxygen species and cathepsin B,” Biochemical and Biophysical Research Communications, vol. 392, no. 2, pp. 160–165, 2010. View at Publisher · View at Google Scholar · View at Scopus
  42. C. Gong, G. Tao, L. Yang, J. Liu, H. He, and Z. Zhuang, “The role of reactive oxygen species in silicon dioxide nanoparticle-induced cytotoxicity and DNA damage in HaCaT cells,” Molecular Biology Reports, vol. 39, no. 4, pp. 4915–4925, 2012. View at Publisher · View at Google Scholar · View at Scopus
  43. Y. Yu, J. Duan, Y. Li et al., “Silica nanoparticles induce autophagy and autophagic cell death in HepG2 cells triggered by reactive oxygen species,” Journal of Hazardous Materials, vol. 270, pp. 176–186, 2014. View at Publisher · View at Google Scholar
  44. R. Foldbjerg, P. Olesen, M. Hougaard, D. A. Dang, H. J. Hoffmann, and H. Autrup, “PVP-coated silver nanoparticles and silver ions induce reactive oxygen species, apoptosis and necrosis in THP-1 monocytes,” Toxicology Letters, vol. 190, no. 2, pp. 156–162, 2009. View at Publisher · View at Google Scholar · View at Scopus
  45. N. Azad, A. K. V. Iyer, L. Wang, Y. Liu, Y. Lu, and Y. Rojanasakul, “Reactive oxygen species-mediated p38 MAPK regulates carbon nanotube-induced fibrogenic and angiogenic responses,” Nanotoxicology, vol. 7, no. 2, pp. 157–168, 2013. View at Publisher · View at Google Scholar · View at Scopus
  46. M. Pacurari, Y. Qian, W. Fu et al., “Cell permeability, migration, and reactive oxygen species induced by multiwalled carbon nanotubes in human microvascular endothelial cells,” Journal of Toxicology and Environmental Health A, vol. 75, no. 3, pp. 129–147, 2012. View at Publisher · View at Google Scholar · View at Scopus
  47. X. He, S. H. Young, D. Schwegler-Berry, W. P. Chisholm, J. E. Fernback, and Q. Ma, “Multiwalled carbon nanotubes induce a fibrogenic response by stimulating reactive oxygen species production, activating NF-κB signaling, and promoting fibroblast-to-myofibroblast transformation,” Chemical Research in Toxicology, vol. 24, no. 12, pp. 2237–2248, 2011. View at Publisher · View at Google Scholar · View at Scopus
  48. P. Andujar, J. Pairon, A. Renier et al., “Differential mutation profiles and similar intronic TP53 polymorphisms in asbestos-related lung cancer and pleural mesothelioma,” Mutagenesis, vol. 28, no. 3, pp. 323–331, 2013. View at Publisher · View at Google Scholar · View at Scopus
  49. H. H. Nelson, D. C. Christiani, J. K. Wiencke, E. J. Mark, J. C. Wain, and K. T. Kelsey, “k-ras Mutation and occupational asbestos exposure in lung adenocarcinoma: asbestos-related cancer without asbestosis,” Cancer Research, vol. 59, no. 18, pp. 4570–4573, 1999. View at Google Scholar · View at Scopus
  50. K. Husgafvel-Pursiainen, P. Hackman, M. Ridanpaa et al., “K-ras mutations in human adenocarcinoma of the lung: association with smoking and occupational exposure to asbestos,” International Journal of Cancer, vol. 53, no. 2, pp. 250–256, 1993. View at Publisher · View at Google Scholar · View at Scopus
  51. K. Husgafvel-Pursiainen, A. Karjalainen, A. Kannio et al., “Lung cancer and past occupational exposure to asbestos role of p53 and K-ras mutations,” The American Journal of Respiratory Cell and Molecular Biology, vol. 20, no. 4, pp. 667–674, 1999. View at Publisher · View at Google Scholar · View at Scopus
  52. A. A. Shvedova, N. Yanamala, E. R. Kisin et al., “Long-term effects of carbon containing engineered nanomaterials and asbestos in the lung: one year postexposure comparisons,” American Journal of Physiology: Lung Cellular and Molecular Physiology, vol. 306, no. 2, pp. L170–L182, 2014. View at Publisher · View at Google Scholar
  53. L. Fialkow, Y. Wang, and G. P. Downey, “Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function,” Free Radical Biology and Medicine, vol. 42, no. 2, pp. 153–164, 2007. View at Publisher · View at Google Scholar · View at Scopus
  54. S. Kar, S. Subbaram, P. M. Carrico, and J. A. Melendez, “Redox-control of matrix metalloproteinase-1: a critical link between free radicals, matrix remodeling and degenerative disease,” Respiratory Physiology and Neurobiology, vol. 174, no. 3, pp. 299–306, 2010. View at Publisher · View at Google Scholar · View at Scopus
  55. C. R. Kliment and T. D. Oury, “Oxidative stress, extracellular matrix targets, and idiopathic pulmonary fibrosis,” Free Radical Biology and Medicine, vol. 49, no. 5, pp. 707–717, 2010. View at Publisher · View at Google Scholar · View at Scopus
  56. E. C. Chan, F. Jiang, H. M. Peshavariya, and G. J. Dusting, “Regulation of cell proliferation by NADPH oxidase-mediated signaling: potential roles in tissue repair, regenerative medicine and tissue engineering,” Pharmacology and Therapeutics, vol. 122, no. 2, pp. 97–108, 2009. View at Publisher · View at Google Scholar · View at Scopus
  57. N. Azad, A. Iyer, V. Vallyathan et al., “Role of oxidative/nitrosative stress-mediated Bcl-2 regulation in apoptosis and malignant transformation,” Annals of the New York Academy of Sciences, vol. 1203, pp. 1–6, 2010. View at Publisher · View at Google Scholar · View at Scopus
  58. Q. Mu, D. L. Broughton, and B. Yan, “Endosomal leakage and nuclear translocation of multiwalled carbon nanotubes: developing a model for cell uptake,” Nano Letters, vol. 9, no. 12, pp. 4370–4375, 2009. View at Publisher · View at Google Scholar · View at Scopus
  59. J. H. Wang, “Mechanisms and impacts of chromosomal translocations in cancers,” Frontiers of Medicine in China, vol. 6, no. 3, pp. 263–274, 2012. View at Publisher · View at Google Scholar · View at Scopus
  60. H. Mano, “Non-solid oncogenes in solid tumors: EML4-ALK fusion genes in lung cancer,” Cancer Science, vol. 99, no. 12, pp. 2349–2355, 2008. View at Publisher · View at Google Scholar · View at Scopus
  61. K. Mecklenburgh, J. Murray, T. Brazil, C. Ward, A. G. Rossi, and E. R. Chilvers, “Role of neutrophil apoptosis in the resolution of pulmonary inflammation,” Monaldi Archives for Chest Disease, vol. 54, no. 4, pp. 345–349, 1999. View at Google Scholar · View at Scopus
  62. T. Iyama and D. M. Wilson III, “DNA repair mechanisms in dividing and non-dividing cells,” DNA Repair, vol. 12, no. 8, pp. 620–636, 2013. View at Publisher · View at Google Scholar · View at Scopus
  63. J. Yuan, L. Narayanan, S. Rockwell, and P. M. Glazer, “Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH,” Cancer Research, vol. 60, no. 16, pp. 4372–4376, 2000. View at Google Scholar · View at Scopus
  64. D. Ramos-Barbón, M. S. Ludwig, and J. G. Martin, “Airway remodeling: lessons from animal models,” Clinical Reviews in Allergy & Immunology, vol. 27, no. 1, pp. 3–21, 2004. View at Google Scholar
  65. L. Cohn, J. A. Elias, and G. L. Chupp, “Asthma: mechanisms of disease persistence and progression,” Annual Review of Immunology, vol. 22, pp. 789–815, 2004. View at Publisher · View at Google Scholar · View at Scopus
  66. J. E. Fish and S. P. Peters, “Airway remodeling and persistent airway obstruction in asthma,” Journal of Allergy and Clinical Immunology, vol. 104, part 1, no. 3, pp. 509–516, 1999. View at Publisher · View at Google Scholar · View at Scopus
  67. K. Ohta, M. Yamaguchi, K. Akiyama et al., “Japanese guideline for adult asthma,” Allergology International, vol. 60, no. 2, pp. 115–145, 2011. View at Publisher · View at Google Scholar · View at Scopus
  68. E. Kuroda, C. Coban, and K. J. Ishii, “Particulate adjuvant and innate immunity: past achievements, present findings, and future prospects,” International Reviews of Immunology, vol. 32, no. 2, pp. 209–220, 2013. View at Publisher · View at Google Scholar · View at Scopus
  69. C. Brandenberger, N. L. Rowley, D. N. Jackson-Humbles et al., “Engineered silica nanoparticles act as adjuvants to enhance allergic airway disease in mice,” Particle and Fibre Toxicology, vol. 10, article 26, no. 1, 2013. View at Publisher · View at Google Scholar · View at Scopus
  70. E. Kuroda, K. J. Ishii, S. Uematsu et al., “Silica crystals and aluminum salts regulate the production of prostaglandin in macrophages via NALP3 inflammasome -independent mechanisms,” Immunity, vol. 34, no. 4, pp. 514–526, 2011. View at Publisher · View at Google Scholar · View at Scopus
  71. S. C. Eisenbarth, O. R. Colegio, W. O'Connor Jr., F. S. Sutterwala, and R. A. Flavell, “Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants,” Nature, vol. 453, no. 7198, pp. 1122–1126, 2008. View at Publisher · View at Google Scholar · View at Scopus
  72. C. Dostert, V. Pétrilli, R. van Bruggen, C. Steele, B. T. Mossman, and J. Tschopp, “Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica,” Science, vol. 320, no. 5876, pp. 674–677, 2008. View at Publisher · View at Google Scholar · View at Scopus
  73. M. Kool, T. Soullié, M. Van Nimwegen et al., “Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells,” Journal of Experimental Medicine, vol. 205, no. 4, pp. 869–882, 2008. View at Publisher · View at Google Scholar · View at Scopus
  74. T. Marichal, K. Ohata, D. Bedoret et al., “DNA released from dying host cells mediates aluminum adjuvant activity,” Nature Medicine, vol. 17, no. 8, pp. 996–1002, 2011. View at Publisher · View at Google Scholar · View at Scopus
  75. A. S. McKee, M. A. Burchill, M. W. Munks et al., “Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 12, pp. E1122–E1131, 2013. View at Publisher · View at Google Scholar · View at Scopus