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Journal of Immunology Research
Volume 2015, Article ID 101879, 8 pages
http://dx.doi.org/10.1155/2015/101879
Research Article

Polymorphisms Associated with Age at Onset in Patients with Moderate-to-Severe Plaque Psoriasis

1Clinical Pharmacology Service, Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria Princesa (IP), Universidad Autónoma de Madrid (UAM), 28006 Madrid, Spain
2Dermatology Service, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria Princesa (IP), 28006 Madrid, Spain
3Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain
4Dermatology Service, Hospital Universitario Gregorio Marañón, 28007 Madrid, Spain
5Dermatology Service, Hospital Universitario Fundación Alcorcón, 28922 Madrid, Spain
6Dermatology Service, Hospital Universitario Infanta Leonor, 28031 Madrid, Spain

Received 18 June 2015; Accepted 15 September 2015

Academic Editor: Fulvia Ceccarelli

Copyright © 2015 Rocío Prieto-Pérez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Psoriasis is a chronic skin disease in which genetics play a major role. Although many genome-wide association studies have been performed in psoriasis, knowledge of the age at onset remains limited. Therefore, we analyzed 173 single-nucleotide polymorphisms in genes associated with psoriasis and other autoimmune diseases in patients with moderate-to-severe plaque psoriasis type I (early-onset, <40 years) or type II (late-onset, ≥40 years) and healthy controls. Moreover, we performed a comparison between patients with type I psoriasis and patients with type II psoriasis. Our comparison of a stratified population with type I psoriasis and healthy controls is the first to reveal a relationship between the CLMN, FBXL19, CCL4L, C17orf51, TYK2, IL13, SLC22A4, CDKAL1, and HLA-B/MICA genes. When we compared type I psoriasis with type II psoriasis , we found a significant association between age at onset and the genes PSORS6, TNF-α, FCGR2A, TNFR1, CD226, HLA-C, TNFAIP3, and CCHCR1. Moreover, we replicated the association between rs12191877 (HLA-C) and type I psoriasis and between type I and type II psoriasis. Our findings highlight the role of genetics in age of onset of psoriasis.