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Journal of Immunology Research
Volume 2015 (2015), Article ID 106904, 8 pages
http://dx.doi.org/10.1155/2015/106904
Research Article

The Value of a Panel of Autoantibodies for Predicting the Activity of Lupus Nephritis at Time of Renal Biopsy

1Division of Nephrology, Fondazione Ospedale Maggiore, Mangiagalli, Regina Elena, 20122 Milano, Italy
2Department of Informatics, Università degli Studi di Pavia, 27100 Pavia, Italy
3Institute of Microbiology, Azienda Ospedaliera, Ospedale San Carlo Borromeo, 20153 Milano, Italy
4Renal Unit and Clinical Immunology Unit, Azienda Ospedaliera, Ospedale San Carlo Borromeo, 20153 Milano, Italy

Received 3 December 2014; Accepted 16 February 2015

Academic Editor: Douglas C. Hooper

Copyright © 2015 Gabriella Moroni et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Cervera, M. A. Khamashta, J. Font et al., “Morbidity and mortality in systemic lupus erythematosus during a 10-year period: a comparison of early and late manifestations in a cohort of 1,000 patients,” Medicine, vol. 82, no. 5, pp. 299–308, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. G. Moroni, S. Quaglini, M. Maccario, G. Banfi, and C. Ponticelli, “'Nephritic flares' are predictors of bad long-term renal outcome in lupus nephritis,” Kidney International, vol. 50, no. 6, pp. 2047–2053, 1996. View at Publisher · View at Google Scholar · View at Scopus
  3. C. T. Ravirajan, L. Rowse, J. R. MacGowan, and D. A. Isenberg, “An analysis of clinical disease activity and nephritis-associated serum autoantibody profiles in patients with systematic lupus erythematosus: a cross-sectional study,” Rheumatology, vol. 40, no. 12, pp. 1405–1412, 2001. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Ho, L. S. Magder, S. G. Barr, and M. Petri, “Decreases in anti-double-stranded DNA levels are associated with concurrent flares in patients with systemic lupus erythematosus,” Arthritis & Rheumatism, vol. 44, no. 10, pp. 2342–2349, 2001. View at Publisher · View at Google Scholar
  5. M. D. Linnik, J. Z. Hu, K. R. Heilbrunn et al., “Relationship between anti-double-stranded DNA antibodies and exacerbation of renal disease in patients with systemic lupus erythematosus,” Arthritis & Rheumatism, vol. 52, no. 4, pp. 1129–1137, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. J. M. Esdaile, M. Abrahamowicz, L. Joseph, T. MacKenzie, Y. Li, and D. Danoff, “Laboratory tests as predictors of disease exacerbations in systemic lupus erythematosus: why some tests fail,” Arthritis and Rheumatism, vol. 39, no. 3, pp. 370–378, 1996. View at Publisher · View at Google Scholar · View at Scopus
  7. C. Bigler, M. Lopez-Trascasa, E. Potlukova et al., “Antinucleosome antibodies as a marker of active proliferative lupus nephritis,” The American Journal of Kidney Diseases, vol. 51, no. 4, pp. 624–629, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. N. Bizzaro, D. Villalta, D. Giavarina, and R. Tozzoli, “Are anti-nucleosome antibodies a better diagnostic marker than anti-dsDNA antibodies for systemic lupus erythematosus? A systematic review and a study of metanalysis,” Autoimmunity Reviews, vol. 12, no. 2, pp. 97–106, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. C. E. H. Siegert, M. R. Daha, C. M. E. S. Tseng, I. E. M. Coremans, L. A. van Es, and F. C. Breedveld, “Predictive value of IgG autoantibodies against C1q for nephritis in systemic lupus erythematosus,” Annals of the Rheumatic Diseases, vol. 52, no. 12, pp. 851–856, 1993. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Trendelenburg, J. Marfurt, I. Gerber, A. Tyndall, and J. A. Schifferli, “Lack of occurrence of severe lupus nephritis among anti-C1q autoantibody-negative patients,” Arthritis & Rheumatism, vol. 42, no. 1, pp. 187–188, 1999. View at Publisher · View at Google Scholar
  11. R. A. Sinico, A. Radice, M. Ikehata et al., “Anti-C1q autoantibodies in lupus nephritis: prevalence and clinical significance,” Annals of the New York Academy of Sciences, vol. 1050, pp. 193–200, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. N. Marto, M. L. Bertolaccini, E. Calabuig, G. R. V. Hughes, and M. A. Khamashta, “Anti-C1q antibodies in nephritis: correlation between titres and renal disease activity and positive predictive value in systemic lupus erythematosus,” Annals of the Rheumatic Diseases, vol. 64, no. 3, pp. 444–448, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. I. E. M. Coremans, P. E. Spronk, H. Bootsma et al., “Changes in antibodies to C1q predict renal relapses in systemic lupus erythematosus,” American Journal of Kidney Diseases, vol. 26, no. 4, pp. 595–601, 1995. View at Publisher · View at Google Scholar · View at Scopus
  14. G. Moroni, M. Trendelenburg, N. Del Papa et al., “Anti-C1q antibodies may help in diagnosing a renal flare in lupus nephritis,” The American Journal of Kidney Diseases, vol. 37, no. 3, pp. 490–498, 2001. View at Publisher · View at Google Scholar · View at Scopus
  15. E. Akhter, R. W. Burlingame, A. L. Seaman, L. Magder, and M. Petri, “Anti-C1q antibodies have higher correlation with flares of lupus nephritis than other serum markers,” Lupus, vol. 20, no. 12, pp. 1267–1274, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. G. Moroni, A. Radice, G. Giammarresi et al., “Are laboratory tests useful for monitoring the activity of lupus nephritis? A 6-year prospective study in a cohort of 228 patients with lupus nephritis,” Annals of the Rheumatic Diseases, vol. 68, no. 2, pp. 234–237, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. M. C. Hochberg, “Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus,” Arthritis and rheumatism, vol. 40, no. 9, p. 1725, 1997. View at Google Scholar · View at Scopus
  18. J. J. Weening, V. D. D'Agati, M. M. Schwartz et al., “The classification of glomerulonephritis in systemic lupus erythematosus revisited,” Journal of the American Society of Nephrology, vol. 15, no. 2, pp. 241–250, 2004. View at Google Scholar
  19. H. A. Austin III, D. T. Boumpas, E. M. Vaughan, and J. E. Balow, “Predicting renal outcomes in severe lupus nephritis: contributions of clinical and histologic data,” Kidney International, vol. 45, no. 2, pp. 544–550, 1994. View at Publisher · View at Google Scholar · View at Scopus
  20. L. Andreoli, F. Pregnolato, R. W. Burlingame et al., “Antinucleosome antibodies in primary antiphospholipid syndrome: a hint at systemic autoimmunity?” Journal of Autoimmunity, vol. 30, no. 1-2, pp. 51–57, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. C. C. Mok, L. Y. Ho, H. W. Leung, and L. G. Wong, “Performance of anti-C1q, antinucleosome, and anti-dsDNA antibodies for detecting concurrent disease activity of systemic lupus erythematosus,” Translational Research, vol. 156, no. 6, pp. 320–325, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Mosca, D. Chimenti, F. Pratesi et al., “Prevalence and clinico-serological correlations of anti-α-enolase, anti-C1q, and anti-dsDNA antibodies in patients with systemic lupus erythematosus,” The Journal of Rheumatology, vol. 33, no. 4, pp. 695–697, 2006. View at Google Scholar · View at Scopus
  23. H. Julkunen, S. Ekblom-Kullberg, and A. Miettinen, “Nonrenal and renal activity of systemic lupus erythematosus: a comparison of two anti-C1q and five anti-dsDNA assays and complement C3 and C4,” Rheumatology International, vol. 32, no. 8, pp. 2445–2451, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Trendelenburg, M. Lopez-Trascasa, E. Potlukova et al., “High prevalence of anti-C1q antibodies in biopsy-proven active lupus nephritis,” Nephrology Dialysis Transplantation, vol. 21, no. 11, pp. 3115–3121, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. X.-W. Yang, Y. Tan, F. Yu, and M.-H. Zhao, “Combination of anti-C1q and anti-dsDNA antibodies is associated with higher renal disease activity and predicts renal prognosis of patients with lupus nephritis,” Nephrology Dialysis Transplantation, vol. 27, no. 9, pp. 3552–3559, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. Q.-Y. Fang, F. Yu, Y. Tan et al., “Anti-C1q antibodies and IgG subclass distribution in sera from Chinese patients with lupus nephritis,” Nephrology Dialysis Transplantation, vol. 24, no. 1, pp. 172–178, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. C. Grootscholten, J. W. C. Dieker, F. D. McGrath et al., “A prospective study of anti-chromatin and anti-C1q autoantibodies in patients with proliferative lupus nephritis treated with cyclophosphamide pulses or azathioprine/methylprednisolone,” Annals of the Rheumatic Diseases, vol. 66, no. 5, pp. 693–696, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. A. Matrat, C. Veysseyre-Balter, P. Trolliet et al., “Simultaneous detection of anti-C1q and anti-double stranded DNA autoantibodies in lupus nephritis: predictive value for renal flares,” Lupus, vol. 20, no. 1, pp. 28–34, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. P. Oelzner, B. Deliyska, R. Fünfstück, G. Hein, D. Herrmann, and G. Stein, “Anti-C1q antibodies and antiendothelial cells antibodies in systemic lupus erythematosus—relationship with disease activity and renal involvement,” Clinical Rheumatology, vol. 22, no. 4-5, pp. 271–278, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. A. Kumar, R. Gupta, T. Varghese, R. M. Pande, V. K. Singal, and O. P. Garg, “Anti-C1q antibody as a marker of disease activity in systemic lupus erythematosus,” Indian Journal of Medical Research, vol. 110, pp. 190–193, 1999. View at Google Scholar · View at Scopus
  31. O. C. Meyer, P. Nicaise-Roland, N. Cadoudal et al., “Anti-C1q antibodies antedate patent active glomerulonephritis in patients with systemic lupus erythematosus,” Arthritis Research & Therapy, vol. 11, no. 3, article R87, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. M. A. Seelen, L. A. Trouw, and M. R. Daha, “Diagnostic and prognostic significance of anti-C1q antibodies in systemic lupus erythematosus,” Current Opinion in Nephrology and Hypertension, vol. 12, no. 6, pp. 619–624, 2003. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Mahler, R. A. van Schaarenburg, and L. A. Trouw, “Anti-C1q autoantibodies, novel tests, and clinical consequences,” Frontiers in Immunology, vol. 4, article 117, 2013. View at Publisher · View at Google Scholar · View at Scopus