Bone-Immune Cell Crosstalk: Bone Diseases

Table 1

Established and possible novel therapeutic targets in the different bone diseases.

(a)

Established therapeutic targets	Pathologies	References
TNF-	PsA	[20]
RANKL	PsA, osteoporosis, MM, and bone metastatic tumors	[22–27]
IL-17	PsA	[29]
IL-23	PsA	[29, 33]
IL-17RA	PsA	[36]

(b)

Possible novel therapeutic targets	Pathologies	References
LIGHT	MM	[21]
DKK1	Bone metastasis and GIO	[28]
IL-17	MM	[30–32]
MDSC targeting	Bone metastasis	[34, 35]