Structural and Computational Biology in the Design of Immunogenic Vaccine Antigens

Figure 2

Broad coverage chimeric fHbp generated by rational design as described in [21]. The surface of variant 1 fHbp used as a scaffold is shown in brown. The engineered area carrying heterologous epitopes is colored in dark red (residues in common between variant 2 (V2) and variant 3 (V3)) and in green (variant 3-specific residues).