Structural and Computational Biology in the Design of Immunogenic Vaccine Antigens

Table 1

Software for antigen discovery.

Software	Vaccine candidate prediction targets			Main selection criteria	Multipass membrane; protein/human homolog detection	Host-pathogen; interactions	MHC; epitopes
	Prokaryotes	Archaea	Eukaryotes	Subcellular localization
Jenner-Predict [32]
NERVE [33]
PSORTb 3.0 [34]
Vacceed [35]
Vaxign [36]
VaxiJen v2.0^1 [37]

VaxiJen uses an alignment-independent approach making it not directly comparable to the other software in the antigen selection criteria.
²Using PSORTb 2.0 for subcellular localization prediction.
³Using PSORTb 3.0 for subcellular localization prediction.