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Journal of Immunology Research
Volume 2015 (2015), Article ID 213836, 10 pages
Review Article

Modulation of Immune Response by Organophosphorus Pesticides: Fishes as a Potential Model in Immunotoxicology

Universidad Autónoma de Nayarit, Secretaría de Investigación y Posgrado, Laboratorio de Inmunotoxicología, Ciudad de la Cultura s/n, 63000 Tepic, NAY, Mexico

Received 25 September 2014; Revised 7 January 2015; Accepted 12 January 2015

Academic Editor: Oscar Bottasso

Copyright © 2015 K. J. G. Díaz-Resendiz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Immune response is modulated by different substances that are present in the environment. Nevertheless, some of these may cause an immunotoxic effect. In this paper, the effect of organophosphorus pesticides (frequent substances spilled in aquatic ecosystems) on the immune system of fishes and in immunotoxicology is reviewed. Furthermore, some cellular and molecular mechanisms that might be involved in immunoregulation mechanisms of organophosphorus pesticides are discussed.