Regulators and Effectors of Arf GTPases in Neutrophils

Table 1

Neutrophil functions modulated by Arfs and their regulators.

Detected in PMNs	Roles in PMNs (or PMN-like cells)	References
Arf1	PLD activation; Secretion; Golgi function	[32–35]
Arf6	PLD activation; NADPH oxidase activity; PIP5-kinase stimulation	[36–38]
CYTH-1	Arf6 activation; PLD activation; FPRL-1 internalization; Regulation of β2 integrins; Adhesion; Chemotaxis; Phagocytosis; NADPH oxidase activity	[37, 39–43]
CYTH-2/3	Unknown	[20, 39]
GBF1	Activation of Arf1; Cell polarisation; Direction sensing; Superoxide production	[44]
GIT2	NADPH oxidase activity; Directional migration; Arf1 inactivation	[44, 45]
ASAP1/2	Unknown	[46]
ACAP1	Unknown	[46]
ARAP1	Unknown	[46, 47]
ARAP3	Regulation of β2 integrins; Adhesion; Chemotaxis; ROS production	[46–49]
AGAP2	Phagocytosis	Unpublished
ADAP2	Unknown	[47]