Effect of TACI Signaling on Humoral Immunity and Autoimmune Diseases

Figure 2

Regulation of TACI expression. Activation TLR4, TLR7, or TLR9 increases TACI expression in B cells. Ligation of CD40 or BCR activation also results in elevated TACI expression in B cells (1). However, IL-21 downregulates TACI expression in GC B cells (2). TACI expression in B cells increases with age before adulthood (3).