Impact of Inflammatory Cytokine Gene Polymorphisms on Developing Acute Graft-versus-Host Disease in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
Table 2
Univariate and multivariate analysis of the variables significantly associated with severe GvHD.
aGvHD
with outcome/ with variant
with outcome/ without variant
Univariate
Multivariate
ODDS ratio
CI 95%
ODDS ratio
CI 95%
IL10-1082GG DNR
II–IV
12/16 (75.0%)
33/85 (38.8%)
3.77
1.33–12.0
0.012
4.50
1.45–16.58
0.008
III-IV
4/16 (25.0%)
7/85 (8.2%)
4.21
1.17–14.65
0.029
5.15
0.95–30.15
0.057
FAS-670CC + CT DNR
II–IV
38/74 (52.3%)
7/27 (25.9%)
2.81
1.12–7.65
0.027
2.90
1.11–8.35
0.029
III-IV
11/74 (14.9%)
0/27 (0%)
9.81
1.20–1274
0.029
ns
TLR4-3612TT DNR
III-IV
11/51 (21.6%)
2/56 (3.4%)
6.82
1.88–36.47
0.002
12.86
2.47–138.8
0.001
IL18-607TT + TG PT
II–IV
39/77 (50.6%)
7/30 (23.3%)
3.08
1.25–8.31
0.014
ns
SSC
III-IV
3.83
1.25–8.51
0.003
6.20
1.40–32.31
0.016
DNR: donor; PT: patient; SSC: source of stem cells; ns: not significant.