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Journal of Immunology Research
Volume 2015, Article ID 254245, 6 pages
Research Article

The Expansion of CD25highIL-10highFoxP3high B Regulatory Cells Is in Association with SLE Disease Activity

1Division of Allergy & Clinical Immunology, Bnai Zion Medical Center, Faculty of Medicine, Technion, 4940 Haifa, Israel
2Rheumatology Unit, Bnai Zion Medical Center, Faculty of Medicine, Technion, 4940 Haifa, Israel
3B. Shine Rheumatology Unit, Rambam Health Care Campus, Faculty of Medicine, Technion, 4940 Haifa, Israel

Received 28 July 2015; Accepted 8 September 2015

Academic Editor: Carlo Perricone

Copyright © 2015 Zahava Vadasz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


B regulatory cells (Bregs) belong to a subgroup of activated B cells tasked with maintaining self-tolerance and preventing autoimmunity. While sharing similar regulatory mechanisms such as IL-10 dependency, they also defer in exhibiting their suppressive effects by expressing Fas-Ligand, TGF-beta, and PDL-1. In this study we show, for the first time, the expansion of Bregs in systemic lupus erythematosus (SLE) patients compared to healthy individuals (18.5 ± 3.052% versus 11.0 ± 1.654%, , resp.). This expansion was also shown to correlate with SLE disease activity (). In addition, Bregs were also expressing and further expanded when stimulated with semaphorin 3A. In sum we show that are an additional subtype of Bregs, involved in regulating SLE disease activity. Being IL-10 expressing, we may assume that they are one of the sources of increased serum IL-10 in SLE patients. Further studies are required in order to assess the relation between high serum IL-10 and Breg cells.