An Animal Model Using Metallic Ions to Produce Autoimmune Nephritis
Table 1
Major histological findings in animals intoxicated with metal ions.
Control
Glomeruli conserved, tubules, interstice, and blood vessels normal
AgNO3
Glomeruli with mesangial moderate hypercellularity, interstitial lymphocyte infiltration, congested blood vessels, edema of convoluted tubules, and the presence of proteinaceous material
CuSO4
Glomerular size increased as Bowman space decreased; podocytes with enlarged volume, thickened membranes, and discrete lymphocytic infiltrates, tubular edema with the luminal presence of proteinaceous material, and diffuse vascular congestion
HgCl2
Glomerulus and Bowman space enlarged, mesangial cell proliferation, podocytes with increased volume, increase in membrane thickness, interstitium with inflammatory infiltrate of neutrophils, and tubules with epithelial edema and presence of acidophilus material
Pb(NO3)2
Glomeruli with slight increase in size, increased Bowman space, increased membrane thickness, discrete inflammatory infiltrate, and tubular edema