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Journal of Immunology Research
Volume 2015, Article ID 315957, 6 pages
Review Article

Comparative Immune Response in Children and Adults with H. pylori Infection

1Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
2Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
3School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
4Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
5Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran

Received 1 March 2015; Accepted 15 April 2015

Academic Editor: Hasan Tarık Atmaca

Copyright © 2015 Alireza Razavi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Helicobacter pylori (H. pylori) infection is generally acquired during early childhood; therefore, the immune response which usually takes place at this age may influence or even determine susceptibility to the infection contributing to the clinical outcomes in adulthood. Several cytokines including IL-6, IL-10, and TGF-β1 as well as Foxp3+ cell numbers have been shown to be higher; however, some other cytokines consisting of IL-1β, IL-17A, and IL-23 are lower in infected children than in infected adults. Immune response to H. pylori infection in children is predominant Treg instead of Th17 cell response. These results indicate that immune system responses probably play a role in persistent H. pylori infection. Childhood H. pylori infection is also associated with significantly lower levels of inflammation and ulceration compared with adults. This review, therefore, aimed to provide critical findings of the available literature about comparative immune system in children and adults with H. pylori infection.