Immunomodulatory Effects Mediated by Serotonin

Table 4

Serotonergic drugs and their effects on the immune system.

Pathology/treatment	Result	Reference
HIV chronic infection/; SSRI (citolopram); Human	↓ Macrophage infectivity; ↓ Viral replication in macrophages and T cells; ↑ NK cell activity	Benton et al., 2010 [57]; Evans et al., 2008 [76]
HCV infection; IFN-α and SSRI (escitalopram); Human	↓ Depression symptoms	Schaefer et al., 2012 [77]
Tendinopathy and facial pain; 5-HT3 antagonist (tropisetron); Human	Analgesic effect	Müller and Stratz, 2004 [78]
Infection with Leishmania donovani; SSRI (sertraline); Balb/c mice	SSRI killed L. donovani promastigotes and intracellular amastigotes	Palit and Ali, 2008 [79]
CT26/luc colon carcinoma-bearing mice; Mirtazapine	↓ T cell infiltration in tumor	Fang et al., 2012 [80]