Research Article

Uniphasic Blanching of the Fingers, Abnormal Capillaroscopy in Nonsymptomatic Digits, and Autoantibodies: Expanding Options to Increase the Level of Suspicion of Connective Tissue Diseases beyond the Classification of Raynaud’s Phenomenon

Table 3

Univariate analysis of Raynaud’s phenomenon secondary to a suspected connective tissue disease versus systemic sclerosis (A) and association of different variables assessed by binomial logistic regression (B).

RP suspected secondary to a connective tissue disease versus systemic sclerosis
OR (95% CI) value

(A) Univariate analysis
 RP duration (years)0.993 (0.984–1.002)0.133
 Number of fingers affected by RP1.04 (0.843–1.284)0.713
 Thumb affected by RP0.587 (0.192–1.795)0.351
 Number of RP colour phases0.634 (0.279–1.438)0.275
 VAS pain1.011 (0.99–1.033)0.305
 VAS severity0.996 (0.975–1.018)0.738
 VAS discomfort1.079 (0.889–1.309)0.443
 ANA positive (nonanticentromere) versus ANA negative2.652 (0.61–11.518) 0.193
 ANA positive (anticentromere) versus ANA negative25 (4.248–147.122)<0.001

(B) Binomial logistic regression
 VAS pain1.067 (1.015–1.122)0.011
 VAS severity0.955 (0.912–0.999)0.049
 ANA positive (nonanticentromere) versus ANA negative2.456 (0.499–12.088) 0.269
 ANA positive (anticentromere) versus ANA negative49.023 (6.566–366.005) <0.001

RP: Raynaud phenomenon; ANA: anti-nuclear antibodies; VAS: visual analogue scale; OR: odds ratio; CI: confidence interval.