Journal of Immunology Research / 2015 / Article / Tab 3

Research Article

Osteoprotegerin Polymorphisms in a Mexican Population with Rheumatoid Arthritis and Generalized Osteoporosis: A Preliminary Report

Table 3

Genotype and allele frequencies of polymorphisms in the TNFRSF11B (OPG) gene in healthy subjects and rheumatoid arthritis (RA) patients.

SNPGenotypesHSRAAlleleHSRAOR
(95% CI)

C950T
rs2073617
CC9 (17.6)28 (43.1)C47 (46.1)82 (63.1)0.010.50 (0.30–0.85)
CT29 (56.9)26 (40)T55 (53.9)48 (36.9)
TT13 (25.5)11 (16.9)

C209T
rs3134070
CC39 (75.0)52 (72.2)C89 (85.6)122 (84.7)1.01.1 (0.53–2.2)
CT11 (21.2)18 (25.0)T15 (14.4)22 (15.3)
TT2 (3.8)2 (2.8)

T245G
rs3134069
AA41 (78.8)66 (85.7)A93 (89.4)142 (92.2)0.510.71 (0.30–1.69)
AC11 (21.2)10 (13)C11 (10.6)12 (7.8)
CC0 (0)1 (1.3)

OPG: osteoprotegerin, SNP: single nucleotide polymorphism, RA: rheumatoid arthritis, HS: healthy subjects, OR: odds ratios, and 95% CI: 95% confidence intervals. In order to compute OR (95% CI) the following alleles were used as reference: in correspondence with the allele of risk: rs2073617 T, rs3134070 T, and rs3134069 C.

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