Journal of Immunology Research / 2015 / Article / Tab 3

Research Article

Osteoprotegerin Polymorphisms in a Mexican Population with Rheumatoid Arthritis and Generalized Osteoporosis: A Preliminary Report

Table 3

Genotype and allele frequencies of polymorphisms in the TNFRSF11B (OPG) gene in healthy subjects and rheumatoid arthritis (RA) patients.

(95% CI)

CC9 (17.6)28 (43.1)C47 (46.1)82 (63.1)0.010.50 (0.30–0.85)
CT29 (56.9)26 (40)T55 (53.9)48 (36.9)
TT13 (25.5)11 (16.9)

CC39 (75.0)52 (72.2)C89 (85.6)122 (84.7)1.01.1 (0.53–2.2)
CT11 (21.2)18 (25.0)T15 (14.4)22 (15.3)
TT2 (3.8)2 (2.8)

AA41 (78.8)66 (85.7)A93 (89.4)142 (92.2)0.510.71 (0.30–1.69)
AC11 (21.2)10 (13)C11 (10.6)12 (7.8)
CC0 (0)1 (1.3)

OPG: osteoprotegerin, SNP: single nucleotide polymorphism, RA: rheumatoid arthritis, HS: healthy subjects, OR: odds ratios, and 95% CI: 95% confidence intervals. In order to compute OR (95% CI) the following alleles were used as reference: in correspondence with the allele of risk: rs2073617 T, rs3134070 T, and rs3134069 C.

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