Osteoprotegerin Polymorphisms in a Mexican Population with Rheumatoid Arthritis and Generalized Osteoporosis: A Preliminary Report

Table 3

Genotype and allele frequencies of polymorphisms in the TNFRSF11B (OPG) gene in healthy subjects and rheumatoid arthritis (RA) patients.

SNP	Genotypes	HS	RA	Allele	HS	RA		OR
								(95% CI)
C950T; rs2073617	CC	9 (17.6)	28 (43.1)	C	47 (46.1)	82 (63.1)	0.01	0.50 (0.30–0.85)
	CT	29 (56.9)	26 (40)	T	55 (53.9)	48 (36.9)
	TT	13 (25.5)	11 (16.9)
C209T; rs3134070	CC	39 (75.0)	52 (72.2)	C	89 (85.6)	122 (84.7)	1.0	1.1 (0.53–2.2)
	CT	11 (21.2)	18 (25.0)	T	15 (14.4)	22 (15.3)
	TT	2 (3.8)	2 (2.8)
T245G; rs3134069	AA	41 (78.8)	66 (85.7)	A	93 (89.4)	142 (92.2)	0.51	0.71 (0.30–1.69)
	AC	11 (21.2)	10 (13)	C	11 (10.6)	12 (7.8)
	CC	0 (0)	1 (1.3)

OPG: osteoprotegerin, SNP: single nucleotide polymorphism, RA: rheumatoid arthritis, HS: healthy subjects, OR: odds ratios, and 95% CI: 95% confidence intervals. In order to compute OR (95% CI) the following alleles were used as reference: in correspondence with the allele of risk: rs2073617 T, rs3134070 T, and rs3134069 C.