Journal of Immunology Research / 2015 / Article / Tab 4

Research Article

Osteoprotegerin Polymorphisms in a Mexican Population with Rheumatoid Arthritis and Generalized Osteoporosis: A Preliminary Report

Table 4

Genotype and allele frequencies of polymorphisms in the TNFRSF11B  (OPG) gene in rheumatoid arthritis (RA) patients with normal and low bone mineral density (BMD).

SNPGenotypesRA with normal BMDRA with low BMDAlleleRA with normal BMDRA with low BMDP OR
(95% CI)

C950T
rs2073617
CC9 (50.0)16 (44.4)C25 (69.4)46 (63.9)0.671.3 (0.55–3.03)
CT7 (38.9)14 (38.9)T 11 (30.6)26 (36.1)
TT2 (11.1)6 (16.7)

C209T
rs3134070
CC17 (81.0)29 (69.0)C37 (88.1)70 (83.3)0.601.5 (0.49–4.43)
CT3 (14.3)12 (28.6)T 5 (11.9)14 (16.7)
TT1 (4.8)1 (2.4)

T245G
rs3134069
AA20 (90.9)39 (88.6)A42 (95.5)82 (93.2)0.721.5 (0.29–7.95)
AC2 (9.1)4 (9.1)C 2 (4.5)6 (6.8)
CC0 (0)1 (2.3)

OPG: osteoprotegerin, SNP: single nucleotide polymorphism, RA: rheumatoid arthritis, BMD: bone mineral density, OR: odds ratios, and 95% CI: 95% confidence intervals. In order to compute OR (95% CI) the following alleles were used as reference: in correspondence with the allele of risk: rs2073617 T, rs3134070 T, and rs3134069 C.

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