Journal of Immunology Research / 2015 / Article / Tab 4

Research Article

Osteoprotegerin Polymorphisms in a Mexican Population with Rheumatoid Arthritis and Generalized Osteoporosis: A Preliminary Report

Table 4

Genotype and allele frequencies of polymorphisms in the TNFRSF11B  (OPG) gene in rheumatoid arthritis (RA) patients with normal and low bone mineral density (BMD).

SNPGenotypesRA with normal BMDRA with low BMDAlleleRA with normal BMDRA with low BMDP OR
(95% CI)

CC9 (50.0)16 (44.4)C25 (69.4)46 (63.9)0.671.3 (0.55–3.03)
CT7 (38.9)14 (38.9)T 11 (30.6)26 (36.1)
TT2 (11.1)6 (16.7)

CC17 (81.0)29 (69.0)C37 (88.1)70 (83.3)0.601.5 (0.49–4.43)
CT3 (14.3)12 (28.6)T 5 (11.9)14 (16.7)
TT1 (4.8)1 (2.4)

AA20 (90.9)39 (88.6)A42 (95.5)82 (93.2)0.721.5 (0.29–7.95)
AC2 (9.1)4 (9.1)C 2 (4.5)6 (6.8)
CC0 (0)1 (2.3)

OPG: osteoprotegerin, SNP: single nucleotide polymorphism, RA: rheumatoid arthritis, BMD: bone mineral density, OR: odds ratios, and 95% CI: 95% confidence intervals. In order to compute OR (95% CI) the following alleles were used as reference: in correspondence with the allele of risk: rs2073617 T, rs3134070 T, and rs3134069 C.

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