Osteoprotegerin Polymorphisms in a Mexican Population with Rheumatoid Arthritis and Generalized Osteoporosis: A Preliminary Report

Table 4

Genotype and allele frequencies of polymorphisms in the TNFRSF11B  (OPG) gene in rheumatoid arthritis (RA) patients with normal and low bone mineral density (BMD).

SNP	Genotypes	RA with normal BMD	RA with low BMD	Allele	RA with normal BMD	RA with low BMD	P	OR
								(95% CI)
C950T; rs2073617	CC	9 (50.0)	16 (44.4)	C	25 (69.4)	46 (63.9)	0.67	1.3 (0.55–3.03)
	CT	7 (38.9)	14 (38.9)	T	11 (30.6)	26 (36.1)
	TT	2 (11.1)	6 (16.7)
C209T; rs3134070	CC	17 (81.0)	29 (69.0)	C	37 (88.1)	70 (83.3)	0.60	1.5 (0.49–4.43)
	CT	3 (14.3)	12 (28.6)	T	5 (11.9)	14 (16.7)
	TT	1 (4.8)	1 (2.4)
T245G; rs3134069	AA	20 (90.9)	39 (88.6)	A	42 (95.5)	82 (93.2)	0.72	1.5 (0.29–7.95)
	AC	2 (9.1)	4 (9.1)	C	2 (4.5)	6 (6.8)
	CC	0 (0)	1 (2.3)

OPG: osteoprotegerin, SNP: single nucleotide polymorphism, RA: rheumatoid arthritis, BMD: bone mineral density, OR: odds ratios, and 95% CI: 95% confidence intervals. In order to compute OR (95% CI) the following alleles were used as reference: in correspondence with the allele of risk: rs2073617 T, rs3134070 T, and rs3134069 C.