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Journal of Immunology Research
Volume 2015, Article ID 380975, 11 pages
Research Article

FluKB: A Knowledge-Based System for Influenza Vaccine Target Discovery and Analysis of the Immunological Properties of Influenza Viruses

1Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, Denmark
2Department of Disease Systems Biology, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, 2200 Copenhagen, Denmark
3Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
4Bioinformatics Centre, Department of Biology, University of Copenhagen, 1017 Copenhagen, Denmark
5Department of Computer Science, Metropolitan College, Boston University, Boston, MA 02215, USA
6Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
7Laboratory of Immunobiology, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA

Received 16 January 2015; Accepted 12 March 2015

Academic Editor: Peirong Jiao

Copyright © 2015 Christian Simon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The supplementary material displays screenshots of the sequence variability tool (S1), the colored display of MSA in the browser (S2), and the consensus and Shannon Entropy graph of a MSA (S3). The supplementary material also describes the collection process of the neutralizing antibodies and the two workflows “The neutralization coverage estimation” and “B-Cell Epitope Mapper” (S4). Finally, the supplementary materials contains the reference sequences used for the protein annotation in FluKB (S5).

  1. Supplementary Materials