Vaccination with an Attenuated Ferritin Mutant Protects Mice against Virulent Mycobacterium tuberculosis

Figure 2

Histopathology of vaccinated and uninfected or Mtb-infected mice lungs. ((a)-(b)) H&E stained lung section of BCG vaccinated (for 8 weeks) and uninfected mice. ((c)-(d)) H&E stained lung section of bfrB vaccinated (for 8 weeks) and uninfected mice. The arrow in (c) shows cellular aggregation. The arrows in (d) show foamy histiocytes. ((e)-(f)) H&E stained lung section of BCG vaccinated (for 8 weeks) and Mtb-infected (for 4 weeks) mice. The arrows in (e) show a multifocal, coalescent granuloma. The arrows in (f) show lymphocyte cuff at the periphery of a granuloma. ((g)-(h)) H&E stained lung section of bfrB vaccinated (for 8 weeks) and Mtb-infected (for 4 weeks) mice. The arrows in (g) show multiple, smaller granulomas (compared to (e)). The arrows in (h) show lymphocyte cuff at the periphery of a granuloma. Magnification: 4x ((a), (c), (e), and (g)) or 40x ((b), (d), (f), and (h)).

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