Modulating p56Lck in T-Cells by a Chimeric Peptide Comprising Two Functionally Different Motifs of Tip from Herpesvirus saimiri

Figure 1

hTip-CSKH induced cell proliferation in human and Aotus cells. (a) PBMC from two Aotus nancymaae and one human donor were treated with 40 μM hTip or hTip-CSKH peptides and assayed for -thymidine incorporation after 48-hour treatment. (b) Human and Aotus PBMC exposed to several hTip-CSKH concentrations were assessed for -thymidine incorporation after 72-hour treatment. Stimulation index percentage (SIP) is shown (see Section 2). Student’s -test statistically significant values () are marked with asterisk ().

(a)

(b)