Modulating p56Lck in T-Cells by a Chimeric Peptide Comprising Two Functionally Different Motifs of Tip from Herpesvirus saimiri

Figure 4

hTip-CSKH induced a decreased cell proliferation in Jurkat cells. (a) Jurkat cells were treated with PHA-P or ionomycin and assayed for -thymidine incorporation after 48-hour treatment. (b) Jurkat cells were treated with hTip, hTip-CSKH for 1 h, and then ionomycin-stimulated and assayed for -thymidine incorporation. Jurkat cells treated with each peptide alone or nontreated peptides were added as controls. Stimulation index percentage (SIP) is shown (see Section 2). NS: nonstimulated; Iono: ionomycin. Student’s -test statistically significant values () are marked with asterisk ().

(a)

(b)